Promel Plus

Take the tablet orally with water, preferably 15-30 minutes before meals. Do not crush or chew the tablet.

Paracetamol primarily acts by inhibiting prostaglandin synthesis in the central nervous system, thereby reducing pain and fever. Domperidone selectively blocks peripheral dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and in the gastrointestinal tract, leading to antiemetic effects and increased gastric motility.

• Hypersensitivity to Paracetamol, Domperidone, or any components of the formulation
• Moderate to severe hepatic impairment
• Moderate to severe cardiac impairment, including prolonged QTc interval
• Known electrolyte disturbances (e.g., hypokalemia, hypomagnesemia)
• Significant gastrointestinal hemorrhage, mechanical obstruction, or perforation
• Prolactin-releasing pituitary tumor (prolactinoma)
• Concomitant use with potent CYP3A4 inhibitors that prolong the QT interval (e.g., ketoconazole, erythromycin, clarithromycin, amiodarone)

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Paracetamol overdose can cause severe hepatotoxicity, potentially leading to liver failure and death. Symptoms may include nausea, vomiting, abdominal pain, and anorexia, often delayed for 24-48 hours. Domperidone overdose can lead to drowsiness, disorientation, and extrapyramidal reactions. Treatment involves gastric lavage, activated charcoal, and supportive measures. For Paracetamol, N-acetylcysteine (NAC) is a specific antidote and should be administered promptly. Cardiac monitoring is essential for Domperidone overdose due to QT prolongation risk.

Paracetamol is generally considered safe during pregnancy when used at recommended doses. Domperidone's use in pregnancy should be avoided unless clearly necessary, as animal studies have shown potential reproductive toxicity. Domperidone is excreted in breast milk and can cause adverse effects in breastfed infants. Use during lactation is generally not recommended, or the lowest effective dose should be used for the shortest duration, with careful monitoring of the infant. Consult a doctor.