Medicine Information

Rebalin

Name: Rebalin
Brand: Rebalin
Rating: 4.5 (117 reviews)

Capsule75 mgAnticonvulsants; Neuropathic pain medicationsATC: N03AX16

Generic Name

Pregabalin

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
rebalin 75 mg capsule	৳ 15.00	৳ 150.00

Description

Overview of the medicine

Rebalin 75 mg Capsule contains Pregabalin, an anticonvulsant used to treat neuropathic pain, epilepsy, and generalized anxiety disorder. It works by decreasing abnormal excitement in the brain.

Uses & Indications

Neuropathic pain (diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury associated neuropathic pain)

Adjunctive therapy for partial-onset seizures in adults

Generalized anxiety disorder (GAD)

Fibromyalgia

Dosage

Adults

Typically initiated at 75 mg twice daily or 50 mg three times daily, which may be increased based on response and tolerability, up to a maximum of 300 mg twice daily or 200 mg three times daily (600 mg/day).

Elderly

Dose adjustments may be necessary due to potential age-related decrease in renal function. Start at a lower dose and titrate cautiously.

Renal_impairment

Dose must be reduced in patients with impaired renal function based on creatinine clearance. For CrCl 30-60 mL/min, 75 mg/day in 2-3 divided doses. For CrCl 15-30 mL/min, 25-50 mg/day in 1-2 divided doses.

How to Take

Take orally with a glass of water, with or without food. Swallow the capsule whole; do not crush, chew, or open.

Mechanism of Action

Pregabalin binds with high affinity to the alpha2-delta (α2-δ) subunit of voltage-gated calcium channels in the central nervous system. This binding is thought to reduce the release of several neurotransmitters, including glutamate, norepinephrine, and substance P, which are involved in pain transmission and seizure activity.

Pharmacokinetics

Onset

Analgesic effects typically observed within 1 week for neuropathic pain. Anxiolytic effects may appear within days to weeks.

Excretion

Primarily excreted unchanged in the urine (approximately 98% of the dose is excreted as unchanged drug).

Half life

Approximately 6.3 hours

Absorption

Rapidly and well absorbed after oral administration, with peak plasma concentrations occurring within 1.5 hours. Oral bioavailability is >90% and is not affected by food.

Metabolism

Negligible; Pregabalin undergoes negligible metabolism in humans. Less than 0.1% of the dose is recovered as metabolites in the urine.

Side Effects

Contraindications

Known hypersensitivity to pregabalin or any component of the formulation

Drug Interactions

Angiotensin-Converting Enzyme (ACE) Inhibitors

May lead to increased risk of peripheral edema, though the mechanism is not fully understood.

CNS Depressants (e.g., alcohol, benzodiazepines, opioids)

Concomitant use may potentiate CNS depression (e.g., sedation, dizziness, somnolence, decreased alertness).

Storage

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is supportive and symptomatic, and hemodialysis may be considered in severe cases as pregabalin is dialyzable.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended for use during lactation as pregabalin is excreted in human milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules30 capsules

Shelf Life

2-3 years from manufacturing date

Availability

Available in pharmacies and hospitals

Approval Status

Approved by major regulatory bodies including DGDA

Patent Status

Generic available (Patent expired for active ingredient)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of pregabalin for its approved indications. Ongoing research continues to explore its potential in other conditions.

Lab Monitoring

Renal function (creatinine clearance) should be monitored, especially in elderly patients or those with pre-existing renal impairment.

Doctor Notes

Caution in patients with renal impairment; dose adjustment is crucial.
Monitor patients for signs of CNS depression, especially with concomitant use of other CNS depressants.
Advise patients on the risk of suicidal thoughts and behavior, and counsel them to report any changes immediately.

Patient Guidelines

Do not stop taking this medicine abruptly without consulting your doctor, as it may cause withdrawal symptoms.
Avoid alcohol consumption while on this medication.
Report any unusual mood changes or suicidal thoughts to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.