Medicine Information

a-b1

Name: a-b1
Brand: a-b1
Rating: 4.5 (117 reviews)

Tablet100 mgVitamin B-complexATC: A11DA01

Generic Name

Thiamine Hydrochloride (Vitamin B1) 100 mg tablet

Manufacturer

Hypothetical Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
a b1 100 mg tablet	৳ 0.86	৳ 8.60

Description

Overview of the medicine

A-B1 100 mg Tablet contains Thiamine Hydrochloride, also known as Vitamin B1. It is an essential water-soluble vitamin required for various metabolic processes, nerve function, and heart health. Used to treat and prevent thiamine deficiency.

Uses & Indications

Prevention and treatment of Thiamine deficiency (Beriberi)

Wernicke-Korsakoff syndrome

Peripheral neuritis associated with alcoholism or pregnancy

Dietary supplement for increased thiamine requirements

Dosage

Adults

For mild deficiency: 10-25 mg daily. For severe deficiency/Beriberi: 100 mg daily or several times daily, as advised by a physician.

Elderly

Same as adult dosage, adjust based on clinical condition.

Renal_impairment

No specific dosage adjustment required, as it is a water-soluble vitamin.

How to Take

Oral administration. Tablets can be taken with or without food.

Mechanism of Action

Thiamine is converted into its active form, thiamine pyrophosphate (TPP), which acts as a coenzyme in carbohydrate metabolism, specifically in the decarboxylation of alpha-keto acids and transketolase reactions.

Pharmacokinetics

Onset

Therapeutic effects may be observed within hours to days for deficiency symptoms.

Excretion

Excreted in the urine primarily as metabolites or unchanged thiamine, especially after high doses.

Half life

Approximately 98 minutes (active metabolite).

Absorption

Readily absorbed from the gastrointestinal tract, primarily in the duodenum, through active transport at low concentrations and passive diffusion at high concentrations. Absorption is dose-dependent and saturable.

Metabolism

Metabolized in the liver to thiamine pyrophosphate (TPP), its active form, and other inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to thiamine or any component of the formulation

Drug Interactions

Alcohol

Chronic alcohol consumption may impair thiamine absorption and utilization.

Diuretics (loop diuretics)

May increase urinary excretion of thiamine, potentially leading to deficiency.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Thiamine has a wide therapeutic index, and overdose is rare with oral administration. Extremely high doses may cause mild gastrointestinal upset or allergic reactions in hypersensitive individuals. Treatment is supportive.

Pregnancy & Lactation

Generally considered safe and essential during pregnancy and lactation. Consult a physician for appropriate dosing.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets30 Tablets100 Tablets

Shelf Life

36 months from manufacturing date

Availability

Pharmacies, drugstores, supermarkets

Approval Status

Approved for dietary supplement and therapeutic use

Patent Status

Expired

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy of thiamine in preventing and treating deficiency states and related neurological conditions.

Lab Monitoring

No routine lab monitoring is required for oral thiamine supplementation. In severe deficiency, thiamine levels or erythrocyte transketolase activity may be monitored.

Doctor Notes

Counsel patients on dietary sources of thiamine.
Monitor for signs of deficiency in high-risk groups (e.g., alcoholics, patients with malabsorption).

Patient Guidelines

Take as directed by your doctor or pharmacist.
Do not exceed the recommended dose.
Store in a cool, dry place away from light and moisture.
If symptoms of deficiency persist, consult your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Thiamine is not known to impair the ability to drive or operate machinery.

Lifestyle Advice

Maintain a balanced diet rich in thiamine-containing foods (whole grains, nuts, seeds, pork).
Limit alcohol consumption, as it can impair thiamine absorption.