Medicine Information

A-Pak

Name: A-Pak
Brand: A-Pak
Rating: 4.5 (117 reviews)

Tablet100 mgBroad-spectrum AntibioticATC: J01CA21

Generic Name

Apakcillin

Manufacturer

PharmaCorp Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
a pak 100 mg tablet	৳ 5.00	৳ 50.00

Description

Overview of the medicine

A-Pak 100 mg Tablet is a broad-spectrum antibiotic used to treat a wide range of bacterial infections. It belongs to the penicillin-like class of antibiotics and works by stopping the growth of bacteria. It is effective against both Gram-positive and Gram-negative bacteria.

Uses & Indications

Upper and lower respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Skin and soft tissue infections (e.g., cellulitis, abscesses)

Otitis media

Pharyngitis/Tonsillitis

Dosage

Adults

100 mg to 250 mg every 8 hours, depending on the severity of the infection. Maximum dose 500 mg every 8 hours.

Elderly

No specific dose adjustment is generally required unless there is significant renal impairment. Monitor renal function.

Renal_impairment

For creatinine clearance 10-30 mL/min: 100 mg every 12 hours. For creatinine clearance <10 mL/min: 100 mg every 24 hours.

How to Take

Take A-Pak 100 mg Tablet orally with a glass of water, with or without food. Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.

Mechanism of Action

Apakcillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial lysis and death. It is bactericidal against susceptible organisms.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved within 1-2 hours after oral administration.

Excretion

Primarily excreted unchanged by the kidneys (glomerular filtration and tubular secretion); about 60-70% of the dose is excreted within 6 hours.

Half life

Approximately 1-1.5 hours in adults with normal renal function.

Absorption

Rapidly and well absorbed from the gastrointestinal tract; bioavailability is approximately 80%. Food may slightly decrease the rate but not the extent of absorption.

Metabolism

Partially metabolized in the liver to inactive metabolites.

Side Effects

Contraindications

Known hypersensitivity to apakcillin, other penicillins, or any component of the formulation.
History of severe allergic reactions (e.g., anaphylaxis) to any beta-lactam antibiotic.

Drug Interactions

Probenecid

May increase and prolong plasma levels of apakcillin by decreasing renal tubular secretion.

Methotrexate

May increase methotrexate toxicity due to decreased renal clearance.

Oral contraceptives

May reduce the effectiveness of oral contraceptives (rarely).

Warfarin and other oral anticoagulants

May increase the anticoagulant effect, requiring closer monitoring of INR.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptoms may include nausea, vomiting, diarrhea, and rarely, seizures. Treatment is symptomatic and supportive. Hemodialysis may be used to remove apakcillin from the circulation in severe cases.

Pregnancy & Lactation

Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Excreted in breast milk in small amounts; use with caution in breastfeeding mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10)30 tablets (3x10)

Shelf Life

24 months from the date of manufacture.

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of Apakcillin in various bacterial infections. Post-marketing surveillance continues to monitor for rare side effects.

Lab Monitoring

Liver function tests (for prolonged therapy)
Renal function tests (especially in patients with pre-existing impairment)
Complete blood count (for prolonged therapy)

Doctor Notes

Assess patient for penicillin allergy history before prescribing. Consider renal function adjustments in elderly and renally impaired patients. Advise patients to complete the full course to prevent resistance.
Monitor for signs of C. difficile infection if prolonged diarrhea occurs post-treatment.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Complete the entire course of treatment, even if you feel better.
Do not share your medicine with others.
Inform your doctor about any allergic reactions or severe side effects.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

A-Pak may cause dizziness or drowsiness in some individuals. If you experience these symptoms, avoid driving or operating heavy machinery.

Lifestyle Advice

Maintain good hygiene to prevent reinfection.
Drink plenty of fluids unless advised otherwise by your doctor.
Avoid alcohol consumption during the course of treatment, as it may exacerbate side effects.