Medicine Information

A-Spasm

Name: A-Spasm
Brand: A-Spasm
Rating: 4.5 (117 reviews)

Tablet5 mgAntispasmodic, AnticholinergicATC: A03AA07

Generic Name

Dicyclomine Hydrochloride

Manufacturer

Example Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
a spasm 5 mg tablet	৳ 1.44	৳ 14.40

Description

Overview of the medicine

A-Spasm 5 mg tablet contains Dicyclomine Hydrochloride, an antispasmodic agent used to relieve smooth muscle spasms of the gastrointestinal tract, especially in conditions like Irritable Bowel Syndrome (IBS).

Uses & Indications

Irritable Bowel Syndrome (IBS)

Functional bowel disorders characterized by smooth muscle spasm (e.g., colonic spasm)

Dosage

Adults

Oral: 5 mg three to four times daily. Dosage may be increased to 10 mg three to four times daily if required, as directed by physician.

Elderly

Lower initial doses may be considered for elderly patients, as directed by physician.

Renal_impairment

Use with caution; dosage adjustment may be necessary in severe renal impairment.

How to Take

Take orally with or without food, as directed by your physician.

Mechanism of Action

Dicyclomine hydrochloride exerts its antispasmodic effect by two mechanisms: a specific anticholinergic (antimuscarinic) effect on acetylcholine receptors and a direct smooth muscle relaxant effect.

Pharmacokinetics

Onset

1-2 hours

Excretion

Approximately 80% excreted in urine and 10% in feces.

Half life

1.8 hours (terminal half-life)

Absorption

Rapidly absorbed after oral administration, peak plasma concentrations reached in 60-90 minutes.

Metabolism

Extensively metabolized in the liver.

Side Effects

Contraindications

Hypersensitivity to dicyclomine or any component of the formulation
Glaucoma
Myasthenia gravis
Urinary obstruction (e.g., prostatic hypertrophy)
Gastrointestinal obstruction
Paralytic ileus
Severe ulcerative colitis
Reflux esophagitis
Unstable cardiovascular status in acute hemorrhage
Infants under 6 months of age

Drug Interactions

Digoxin

May increase digoxin serum levels.

Antacids

May decrease the absorption of dicyclomine. Administer dicyclomine at least 2 hours before or after antacids.

Metoclopramide

Antagonistic effects on GI motility.

Other anticholinergics

Increased risk of anticholinergic side effects.

CNS depressants (e.g., alcohol, benzodiazepines)

Enhanced sedative effects.

Storage

Store below 30°C, in a dry place, away from light. Keep out of reach of children.

Overdose

Symptoms of overdose include central nervous system (CNS) stimulation, agitation, delirium, coma, hallucinations, tachycardia, hyperthermia, hypertension, and respiratory depression. Management is supportive, including gastric lavage, activated charcoal, and symptomatic treatment. Physostigmine may be considered for severe anticholinergic symptoms.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Dicyclomine is excreted in breast milk; breastfeeding is not recommended.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved (for general use)

Patent Status

Off-patent

Clinical Trials

Dicyclomine has been studied in numerous clinical trials for its efficacy in treating symptoms of Irritable Bowel Syndrome (IBS) and other functional gastrointestinal disorders, demonstrating significant reduction in abdominal pain and spasm compared to placebo.

Lab Monitoring

No routine lab monitoring is required for dicyclomine. Monitor for adverse effects.

Doctor Notes

Caution in patients with benign prostatic hyperplasia due to risk of urinary retention.
Monitor for signs of CNS effects, especially in elderly patients.
Not recommended for infants under 6 months due to risk of respiratory depression and seizures.

Patient Guidelines

Do not exceed the prescribed dose.
Inform your doctor about all medications you are taking.
Avoid driving or operating machinery if you experience dizziness or blurred vision.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.