Medicine Information

Aceclora

Name: Aceclora
Brand: Aceclora
Rating: 4.5 (117 reviews)

Tablet100 mgNon-steroidal Anti-inflammatory Drugs (NSAIDs)ATC: M01AB16

Generic Name

Aceclofenac

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aceclora 100 mg tablet	৳ 3.02	N/A

Description

Overview of the medicine

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Uses & Indications

Osteoarthritis

Rheumatoid arthritis

Ankylosing spondylitis

Other painful inflammatory conditions like lumbago, periarthritis of shoulder, tendinitis, tenosynovitis

Dosage

Adults

100 mg twice daily, preferably with or after food.

Elderly

No specific dosage adjustment is usually necessary, but caution should be exercised due to potential renal or hepatic impairment and concomitant medication use. The lowest effective dose should be used.

Renal_impairment

For mild to moderate renal impairment, no dosage adjustment is typically needed, but monitor patients carefully. Avoid in severe renal impairment.

Hepatic_impairment

For mild hepatic impairment, an initial daily dose of 100 mg may be sufficient. Use with caution and monitor liver function. Avoid in severe hepatic impairment.

How to Take

Administer orally. It is recommended to take the tablet with or after food to minimize gastrointestinal discomfort.

Mechanism of Action

Aceclofenac acts primarily by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for the synthesis of prostaglandins, mediators of pain and inflammation.

Pharmacokinetics

Onset

Pain relief may begin within approximately 1 hour.

Excretion

Approximately two-thirds of the dose is excreted in the urine, mainly as hydroxylated metabolites, and about one-third via the faeces.

Half life

Approximately 4-4.3 hours.

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1.25 to 3 hours.

Metabolism

Extensively metabolized in the liver, primarily via CYP2C9, to its main metabolite, 4'-hydroxyaceclofenac.

Side Effects

Contraindications

Hypersensitivity to aceclofenac or any other NSAID (e.g., aspirin, ibuprofen)
Active gastrointestinal bleeding or peptic ulcer
Severe renal or hepatic impairment
Severe heart failure
Third trimester of pregnancy
Patients in whom aspirin or other NSAIDs precipitate attacks of asthma, urticaria, or acute rhinitis

Drug Interactions

Digoxin

May increase plasma digoxin levels.

Lithium

May increase plasma lithium levels, requiring dosage adjustment.

Methotrexate

Increased plasma levels of methotrexate and enhanced toxicity.

Corticosteroids

Increased risk of gastrointestinal ulceration or bleeding.

Diuretics and ACE inhibitors

May reduce the natriuretic effect of diuretics and the antihypertensive effect of ACE inhibitors, and increase the risk of renal impairment.

Anticoagulants (e.g., Warfarin)

Increased risk of gastrointestinal bleeding.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, rarely diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting, and convulsions. Management is primarily symptomatic and supportive, including gastric lavage and activated charcoal.

Pregnancy & Lactation

Pregnancy Category C in first and second trimesters, D in third trimester. Avoid in the third trimester due to potential adverse effects on the fetal cardiovascular system (premature closure of the ductus arteriosus). Use with caution during lactation; small amounts may pass into breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets/strip30 tablets/box

Shelf Life

Typically 2-3 years from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

Clinical Trials

Numerous clinical trials have established the efficacy and safety of aceclofenac in various inflammatory and painful conditions, comparing it with other NSAIDs and placebos.

Lab Monitoring

Renal function tests (serum creatinine, BUN) periodically, especially in long-term use or in patients with pre-existing renal impairment.
Liver function tests (ALT, AST) periodically, especially in long-term use or in patients with pre-existing hepatic impairment.
Complete blood count (CBC) with differential for long-term therapy to monitor for anemia and other blood dyscrasias.

Doctor Notes

Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Monitor patients for signs and symptoms of cardiovascular events, gastrointestinal adverse effects, and renal toxicity, especially in high-risk groups (elderly, pre-existing conditions).
Advise patients about potential drug interactions, particularly with anticoagulants and other NSAIDs.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor. Do not exceed the recommended dose.
Always take this tablet with or after food to reduce the risk of stomach upset.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Report any unusual symptoms such as severe stomach pain, black or tarry stools, or swelling in your ankles immediately to your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Aceclofenac may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating heavy machinery.

Lifestyle Advice

Avoid alcohol consumption while taking this medication as it may increase the risk of stomach irritation and bleeding.
Maintain adequate hydration throughout the day.
For chronic conditions, combine medication with appropriate physical therapy or lifestyle modifications as advised by your physician.