Medicine Information

Acefra

Name: Acefra
Brand: Acefra
Rating: 4.5 (117 reviews)

Oral Suspension125 mg/5 mlThird Generation CephalosporinsATC: J01DD08

Generic Name

acefra-125-mg-suspension

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
acefra 125 mg suspension	৳ 78.00	N/A

Description

Overview of the medicine

Acefra 125 mg Suspension is an oral antibiotic belonging to the third-generation cephalosporin class. It contains Cefixime as its active ingredient and is used to treat a wide range of bacterial infections in children.

Uses & Indications

Urinary tract infections (uncomplicated)

Otitis media

Pharyngitis and tonsillitis

Acute bronchitis and acute exacerbations of chronic bronchitis

Uncomplicated gonorrhea

Dosage

Adults

Adults typically use higher strength tablets (e.g., 200-400 mg daily). This suspension is generally for pediatric use.

Elderly

Dosage adjustment is not generally required unless there is severe renal impairment.

Children

8 mg/kg/day administered as a single dose or in two divided doses every 12 hours for 5 to 10 days. Max 400 mg/day.

Renal_impairment

For creatinine clearance 21-60 mL/min, 75% of the standard dose should be given. For creatinine clearance <20 mL/min, 50% of the standard dose should be given.

How to Take

Shake the bottle well before each use. Administer orally with a measuring spoon or cup. Can be taken with or without food.

Mechanism of Action

Cefixime acts by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains essential for bacterial cell wall integrity.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved within 2-6 hours after administration.

Excretion

Primarily excreted unchanged in the urine (about 50-60% of the absorbed dose) and some biliary excretion.

Half life

The plasma elimination half-life is typically 3-4 hours.

Absorption

Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly affect the extent of absorption.

Metabolism

Cefixime is not extensively metabolized in the body; about 10% may undergo hepatic metabolism.

Side Effects

Contraindications

Known hypersensitivity to Cefixime, other cephalosporins, or penicillins.

Drug Interactions

Warfarin

Increased prothrombin time (INR) and bleeding risk. Close monitoring of coagulation parameters is recommended.

Carbamazepine

Increased plasma concentrations of Carbamazepine when co-administered with Cefixime.

Oral Anticoagulants

Enhanced anticoagulant effect.

Storage

Store the dry powder below 30°C in a dry place. Protect from light. Store the reconstituted suspension in a refrigerator (2-8°C). Do not freeze.

Overdose

Gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive treatment is recommended.

Pregnancy & Lactation

Pregnancy Category B. Use with caution during lactation; small amounts are excreted in breast milk. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

50 ml bottle (after reconstitution)100 ml bottle (after reconstitution)

Shelf Life

Shelf life of dry powder is typically 24-36 months. Reconstituted suspension is stable for 7-14 days when stored correctly.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Expired

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections across different age groups, particularly in pediatric populations for oral suspension formulations.

Lab Monitoring

Monitor renal function in patients with pre-existing renal impairment or during prolonged therapy.
Rarely, complete blood count (CBC) may be monitored.

Doctor Notes

Emphasize the importance of completing the full prescribed course to prevent resistance and ensure eradication of infection.
Counsel parents on proper measurement and administration techniques for pediatric suspension.
Be vigilant for signs of Clostridioides difficile-associated diarrhea (CDAD) during or after treatment.

Patient Guidelines

Complete the full course of treatment as prescribed by the doctor, even if symptoms improve.
Shake the bottle well before each dose.
Use the provided measuring device for accurate dosing.
Do not share this medicine with others, even if they have similar symptoms.