Medicine Information

Acerux-3

Name: Acerux-3
Brand: Acerux-3
Rating: 4.5 (117 reviews)

Ophthalmic Ointment0.3% w/wAntibiotic (Ophthalmic)ATC: S01AE08

Generic Name

Aceruacin 0.3% Eye Ointment

Manufacturer

PharmaCorp Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
acerux 3 eye ointment	৳ 45.17	N/A

Description

Overview of the medicine

Acerux-3 Eye Ointment contains Aceruacin 0.3%, a broad-spectrum fluoroquinolone antibiotic, effective against a wide range of gram-positive and gram-negative bacteria causing ocular infections. It is indicated for the treatment of bacterial conjunctivitis, keratitis, and other superficial eye infections.

Uses & Indications

Bacterial conjunctivitis

Bacterial keratitis

Blepharitis

Other superficial ocular bacterial infections

Dosage

Adults

Apply a small ribbon (approx. 1/2 inch) into the conjunctival sac 2-3 times daily for 7-10 days, or as directed by physician.

Elderly

No specific dose adjustment required for elderly patients.

Renal_impairment

No dose adjustment required for renal impairment due to minimal systemic absorption.

How to Take

Wash hands before and after application. Tilt head back, pull down the lower eyelid to form a pocket. Apply a small amount of ointment into the pocket. Close eye gently and roll eyeball to spread the ointment. Avoid touching the tip of the tube to the eye or any other surface.

Mechanism of Action

Aceruacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA, preventing bacterial growth and reproduction, ultimately resulting in bacterial cell death.

Pharmacokinetics

Onset

Clinical improvement often observed within 2-3 days.

Excretion

Primarily excreted via the lacrimal system and superficial ocular washout. Any systemically absorbed drug is likely renally excreted.

Half life

Not well characterized systemically due to minimal absorption; ocular tissue half-life is longer, supporting twice-daily dosing.

Absorption

Minimal systemic absorption after topical ocular administration. High concentrations are achieved in ocular tissues.

Metabolism

Negligible systemic metabolism; localized metabolism in ocular tissues is not significant.

Side Effects

Contraindications

Hypersensitivity to Aceruacin or other fluoroquinolones
Viral or fungal ocular infections (unless co-treated with appropriate agents)

Drug Interactions

Systemic Fluoroquinolones

Though systemic absorption is minimal, theoretical risk of additive adverse effects with systemic fluoroquinolones exists (e.g., tendon issues), though extremely rare.

Other Ophthalmic Preparations

If using multiple ophthalmic medications, allow at least 5 minutes between applications.

Storage

Store at controlled room temperature (15-30°C). Do not freeze. Keep out of reach of children. Protect from light and moisture.

Overdose

Due to the topical nature and minimal systemic absorption, an acute overdose is unlikely. If excessive amount is applied, it can be wiped from the eye. In case of accidental ingestion, seek medical advice.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Caution should be exercised when administered to a nursing mother. Consult a doctor before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

3.5 gm tube

Shelf Life

24 months from manufacturing date, 28 days after opening.

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Patent Expired

Clinical Trials

Clinical trials demonstrated Aceruacin's non-inferiority to other established ophthalmic antibiotics in treating bacterial conjunctivitis and keratitis, with a good safety profile.

Lab Monitoring

No specific laboratory monitoring required for topical ocular Aceruacin.

Doctor Notes

Advise patients on proper application technique to minimize contamination.
Emphasize completing the full course of therapy to prevent recurrence and resistance.
Counsel patients on potential temporary blurred vision and precautions for driving.

Patient Guidelines

Complete the full course of treatment even if symptoms improve.
Do not wear contact lenses during treatment for ocular infections.
Avoid touching the tip of the applicator to prevent contamination.
If irritation persists or worsens, consult your doctor.

Missed Dose Advice

If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not apply a double dose to make up for a missed one.

Driving Precautions

May cause temporary blurred vision after application. Avoid driving or operating machinery until vision clears.

Lifestyle Advice

Maintain good eye hygiene.
Avoid rubbing eyes.
Protect eyes from dust and irritants.

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