Medicine Information

Aceta-Extend

Name: Aceta-Extend
Brand: Aceta-Extend
Rating: 4.5 (117 reviews)

Tablet665 mgAnalgesic, AntipyreticATC: N02BE01

Generic Name

Acetaminophen (Extended Release) 665 mg Tablet

Manufacturer

XYZ Pharmaceuticals

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aceta extend 665 mg tablet	৳ 2.00	৳ 20.00

Description

Overview of the medicine

Aceta-Extend 665 mg Tablet is an extended-release formulation of acetaminophen, used for the relief of mild to moderate pain and to reduce fever. Its extended-release characteristic provides longer-lasting pain relief.

Uses & Indications

Relief of mild to moderate pain (e.g., headache, muscle pain, menstrual pain, toothache, osteoarthritis pain).

Reduction of fever.

Dosage

Adults

Typically, 2 tablets (1330 mg) every 8 hours, not to exceed 6 tablets (3990 mg) in 24 hours.

Elderly

Similar to adult dosage, but caution with hepatic or renal impairment. Consult a physician.

Renal_impairment

Dosage adjustment may be necessary in severe renal impairment. Consult a physician.

How to Take

Take orally with a full glass of water. Do not crush, chew, or dissolve the tablet, as this may destroy the extended-release mechanism.

Mechanism of Action

Acetaminophen primarily acts in the central nervous system by inhibiting prostaglandin synthesis, which is responsible for its analgesic and antipyretic effects. It also blocks pain impulse generation peripherally to a lesser extent.

Pharmacokinetics

Onset

Onset of analgesic action typically within 30-60 minutes, with sustained action due to extended release.

Excretion

Excreted primarily in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.

Half life

Plasma half-life of 2-4 hours, but the extended-release formulation extends the therapeutic effect.

Absorption

Rapidly and extensively absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved slower with extended-release formulations, typically within 2-4 hours, providing sustained release.

Metabolism

Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by the cytochrome P450 enzyme system to a toxic intermediate (NAPQI), which is normally detoxified by conjugation with glutathione.

Side Effects

Contraindications

Hypersensitivity to acetaminophen or any component of the formulation.
Severe hepatic impairment or active liver disease.

Drug Interactions

Alcohol

Concurrent use with alcohol increases the risk of hepatotoxicity.

Other hepatotoxic drugs

May increase the risk of liver damage when co-administered.

Warfarin and other anticoagulants

May increase the anticoagulant effect, leading to an increased risk of bleeding, especially with prolonged daily use.

Storage

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include nausea, vomiting, abdominal pain, and sweating, which may progress to liver failure. Severe overdose can be fatal. Management involves immediate medical attention, gastric decontamination if recent ingestion, and administration of N-acetylcysteine (NAC) as an antidote.

Pregnancy & Lactation

Generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a healthcare professional before use. Prolonged high-dose use should be avoided.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets/Box30 Tablets/Box

Shelf Life

Generally 2-3 years from the date of manufacture, specific to product details.

Availability

Pharmacies, Drug Stores

Approval Status

Approved

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

Acetaminophen has been extensively studied for its efficacy and safety in various pain and fever conditions. Extended-release formulations have undergone trials to demonstrate sustained action and pharmacokinetic profiles suitable for chronic pain management.

Lab Monitoring

Liver function tests (ALT, AST, bilirubin) in cases of chronic use, high doses, or suspected overdose.
Renal function tests if long-term use in patients with renal impairment.

Doctor Notes

Assess patient's liver function, especially if prescribing for chronic pain or if the patient has pre-existing liver conditions.
Educate patients about the risks of exceeding the maximum daily dose and concurrent use of other acetaminophen-containing products.
Consider alternative analgesics for patients with severe hepatic impairment.

Patient Guidelines

Do not exceed the recommended dose to avoid serious liver damage.
Do not take with other acetaminophen-containing products.
If pain or fever persists or worsens, consult your doctor.
Avoid or limit alcohol consumption while taking this medication.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.