Medicine Information

Acifix

Name: Acifix
Brand: Acifix
Rating: 4.5 (117 reviews)

Tablet20 mgProton Pump Inhibitors (PPIs)ATC: A02BC05

Generic Name

Esomeprazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
acifix 20 mg tablet	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Acifix 20 mg tablet contains Esomeprazole, which is a proton pump inhibitor (PPI). It works by reducing the amount of acid your stomach makes, providing relief from symptoms such as heartburn, acid reflux, and helping to heal ulcers.

Uses & Indications

Gastroesophageal Reflux Disease (GERD): treatment of erosive esophagitis, long-term management of patients with healed esophagitis to prevent relapse, symptomatic treatment of GERD.

Healing of Duodenal Ulcers associated with H. pylori (in combination with appropriate antibiotics).

Treatment of Gastric Ulcers associated with H. pylori (in combination with appropriate antibiotics).

Treatment and prevention of NSAID-associated gastric ulcers.

Zollinger-Ellison Syndrome and other pathological hypersecretory conditions.

Dosage

Adults

GERD (Erosive Esophagitis): 20 mg or 40 mg once daily for 4 to 8 weeks. GERD (Symptomatic): 20 mg once daily for 4 weeks. H. pylori eradication: 20 mg twice daily for 7-14 days (in combination with antibiotics).

Elderly

No specific dose adjustment is generally required, but caution should be exercised due to potential for reduced hepatic function.

Renal_impairment

No dose adjustment is required in patients with renal impairment.

How to Take

Acifix tablets should be swallowed whole with water. Do not chew or crush. It is best taken at least one hour before a meal.

Mechanism of Action

Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells. This irreversible binding blocks the final step of acid secretion, leading to a sustained reduction in gastric acid production.

Pharmacokinetics

Onset

Within 1 hour of administration.

Excretion

Approximately 80% of metabolites are excreted in the urine and 20% in the feces.

Half life

Approximately 1.5 hours.

Absorption

Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours. Bioavailability is approximately 64% after a single 20 mg dose, increasing to 89% with repeated once-daily dosing.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.

Side Effects

Contraindications

Known hypersensitivity to Esomeprazole, other substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Warfarin

Increased INR/PT has been reported, requiring monitoring.

Clopidogrel

Esomeprazole may reduce the antiplatelet activity of clopidogrel, especially in CYP2C19 poor metabolizers.

Methotrexate

May increase methotrexate levels, especially in high-dose therapy.

Atazanavir/Nelfinavir

Reduced plasma concentrations of atazanavir and nelfinavir due to increased gastric pH.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Limited experience with overdose. Symptoms may include drowsiness, tachycardia, nausea, diarrhea, and headache. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister, 30 tablets per box

Shelf Life

24 months from the date of manufacture

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of esomeprazole in various acid-related disorders, showing superior or comparable acid suppression to other PPIs and promoting healing of mucosal lesions.

Lab Monitoring

Monitor serum magnesium levels periodically in patients expected to be on long-term treatment or who take PPIs with other drugs that may cause hypomagnesemia.
Monitor INR/PT in patients on concomitant warfarin.

Doctor Notes

Assess the necessity of long-term PPI therapy; consider stepping down to a lower dose or discontinuing if appropriate.
Counsel patients on potential long-term risks, including bone fractures and C. difficile infection.
Monitor for symptoms of hypomagnesemia in patients on prolonged therapy.

Patient Guidelines

Take Acifix exactly as prescribed by your doctor.
Do not chew or crush the tablet; swallow it whole.
Take the medicine at least one hour before a meal.
Inform your doctor if your symptoms do not improve or worsen.
Do not stop taking the medicine abruptly without consulting your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Acifix may cause dizziness, blurred vision, or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.

Lifestyle Advice

Avoid foods and drinks that trigger your acid reflux symptoms (e.g., spicy foods, fatty foods, caffeine, alcohol).
Eat smaller, more frequent meals instead of large ones.
Elevate the head of your bed when sleeping.