Medicine Information

Aciphin

Name: Aciphin
Brand: Aciphin
Rating: 4.5 (117 reviews)

Injection (powder for solution)2 gmAntibioticsATC: J01DD04

Generic Name

Ceftriaxone

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aciphin 2 gm injection	৳ 320.00	N/A

Description

Overview of the medicine

Aciphin 2 gm Injection contains Ceftriaxone, a third-generation cephalosporin antibiotic used to treat various bacterial infections.

Uses & Indications

Lower respiratory tract infections

Skin and skin structure infections

Urinary tract infections

Pelvic inflammatory disease

Bacterial septicemia

Bone and joint infections

Intra-abdominal infections

Meningitis

Surgical prophylaxis

Gonorrhea

Dosage

Adults

Typical dosage is 1-2 gm once daily (or in two divided doses) via IV or IM route, depending on the severity of infection. Max 4 gm/day.

Elderly

No specific dose adjustment required unless severe renal or hepatic impairment.

Renal_impairment

No dosage adjustment needed for mild to moderate impairment. For severe impairment (CrCl < 10 mL/min) or dialysis, close monitoring and dose reduction may be considered.

How to Take

For IV administration, reconstitute with sterile water for injection and administer over 30 minutes. For IM, reconstitute with lidocaine 1% (without epinephrine) and administer deeply into a large muscle.

Mechanism of Action

Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and bacterial death.

Pharmacokinetics

Onset

Rapid onset of action, typically within 1 hour.

Excretion

About 50-60% excreted unchanged in urine via glomerular filtration, and 35-45% excreted via bile and feces.

Half life

Approximately 6-9 hours (longer in neonates and elderly).

Absorption

Well absorbed after intramuscular (IM) or intravenous (IV) administration. Peak plasma concentrations reached within 2-3 hours after IM.

Metabolism

Not extensively metabolized; primarily converted to inactive metabolites in the gut flora.

Side Effects

Contraindications

Hypersensitivity to ceftriaxone, any other cephalosporin, or penicillin
Neonates with hyperbilirubinemia
Premature neonates
Concomitant use with IV calcium-containing solutions in neonates

Drug Interactions

Aminoglycosides

Synergistic effect, but potential for increased nephrotoxicity.

Calcium-containing solutions

Formation of ceftriaxone-calcium precipitates, especially in neonates; avoid concomitant administration.

Loop diuretics (e.g., Furosemide)

Increased risk of nephrotoxicity.

Oral anticoagulants (e.g., Warfarin)

May increase anticoagulant effect; monitor INR.

Storage

Store below 30°C in a dry place, away from light and moisture. Reconstituted solution is stable for 6 hours at room temperature or 24 hours under refrigeration.

Overdose

In case of overdose, symptomatic and supportive treatment is recommended. Hemodialysis and peritoneal dialysis are not effective for removing ceftriaxone.

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in low concentrations in breast milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial (2 gm) + 1 ampoule (10 mL sterile water for injection)

Shelf Life

Usually 24-36 months from manufacturing date.

Availability

Hospitals, Clinics, Pharmacies

Approval Status

Approved by regulatory authorities worldwide (e.g., FDA, DGDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Ceftriaxone has undergone extensive clinical trials supporting its efficacy and safety for various bacterial infections since its introduction. Ongoing research often focuses on resistance patterns and new indications.

Lab Monitoring

Complete blood count (CBC) if prolonged use
Liver function tests (LFTs) periodically
Renal function tests (RFTs) if renal impairment is suspected or prolonged use
INR if co-administered with anticoagulants

Doctor Notes

Confirm bacterial infection before initiating treatment.
Monitor for signs of superinfection.
Adjust dose in severe hepatic or renal impairment.
Avoid co-administration with calcium-containing IV solutions in neonates.

Patient Guidelines

Complete the full course of treatment even if symptoms improve.
Report any severe allergic reactions immediately.
Do not use for viral infections.
Inform your doctor if you have a history of allergies to antibiotics.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.