Medicine Information

Aclene Plus

Name: Aclene Plus
Brand: Aclene Plus
Rating: 4.5 (117 reviews)

GelAdapalene 0.1% / Benzoyl Peroxide 2.5%Anti-acne preparations, Retinoids for topical use, CombinationsATC: D10AD53

Generic Name

Adapalene 0.1% + Benzoyl Peroxide 2.5% Gel

Manufacturer

XYZ Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aclene plus 01 25 gel	৳ 150.00	N/A

Description

Overview of the medicine

Aclene Plus Gel is a combination topical medication containing Adapalene (a retinoid-like compound) and Benzoyl Peroxide. It is primarily used for the treatment of acne vulgaris in patients 9 years of age and older. It works by reducing the formation of comedones and killing acne-causing bacteria.

Uses & Indications

Treatment of acne vulgaris in patients 9 years of age and older.

Dosage

Adults

Apply a thin layer of the gel to affected areas of the face and/or trunk once daily in the evening after washing gently with a non-medicated cleanser and patting dry.

Elderly

No specific dosage adjustments are required for elderly patients.

Renal_impairment

No dosage adjustment is necessary for patients with renal impairment due to minimal systemic absorption.

How to Take

For topical dermatological use only. Apply to clean, dry skin. Avoid contact with eyes, lips, nostrils, and mucous membranes. Wash hands thoroughly after application.

Mechanism of Action

Adapalene modulates cellular differentiation, keratinization, and inflammatory processes. It normalizes differentiation of follicular epithelial cells, resulting in decreased microcomedone formation. Benzoyl Peroxide is an oxidizing agent with bactericidal and keratolytic effects. It kills Propionibacterium acnes (now Cutibacterium acnes) by releasing free oxygen radicals and aids in shedding dead skin cells.

Pharmacokinetics

Onset

Significant improvement is typically observed after 1-4 weeks of daily application, with continued improvement over time.

Excretion

Adapalene is primarily excreted by the biliary route. Benzoic acid (from benzoyl peroxide) is excreted in the urine.

Half life

Due to minimal systemic absorption, plasma half-life values are not clinically relevant for topical administration.

Absorption

Systemic absorption of adapalene and benzoyl peroxide is minimal following topical application. Adapalene plasma concentrations are generally below the quantification limit (0.1 ng/mL). Benzoyl peroxide is rapidly metabolized to benzoic acid after skin penetration and then excreted.

Metabolism

Topically applied adapalene is metabolized to more polar conjugates, primarily via O-demethylation, in the liver. Benzoyl peroxide is converted to benzoic acid in the skin.

Side Effects

Contraindications

Hypersensitivity to adapalene, benzoyl peroxide, or any component of the gel.
Pregnancy (consult a doctor).

Drug Interactions

Topical preparations with irritating or drying effects

Avoid concomitant use as it may lead to cumulative irritation, especially with sulfur, resorcinol, or salicylic acid. If used, apply at different times of the day.

Products containing alpha hydroxy acids or glycolic acid

Concurrent use may increase skin irritation.

Storage

Store below 30°C in a dry place. Protect from light and freezing. Keep out of reach of children.

Overdose

Topical overdose may result in marked redness, peeling, or discomfort. Systemic effects from an accidental topical overdose are unlikely due to the minimal percutaneous absorption. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether adapalene or benzoyl peroxide is excreted in human milk after topical application; exercise caution when administering to a nursing mother. Consult a physician before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

15g tube30g tube

Shelf Life

Typically 24 to 36 months from manufacturing date.

Availability

Available in pharmacies nationwide

Approval Status

Approved (DGDA, FDA equivalent)

Patent Status

Off-patent (Generic available)

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of adapalene 0.1% and benzoyl peroxide 2.5% combination gel in the treatment of acne vulgaris.

Lab Monitoring

No specific laboratory monitoring is required for this topical medication.

Doctor Notes

Emphasize proper application technique and patient education on potential side effects and sun protection.
Advise patients on the importance of consistency and patience for optimal results.
Monitor for excessive irritation and adjust treatment regimen as needed.

Patient Guidelines

Apply sparingly to the entire affected area, not just individual lesions.
Avoid excessive sun exposure and use sunscreen with SPF 15 or higher.
Moisturizers can be used to alleviate dryness or irritation.
Do not apply to cuts, abrasions, eczematous skin, or sunburned skin.

Missed Dose Advice

If a dose is missed, do not apply a double dose to make up for it. Simply apply the next scheduled dose in the evening.

Driving Precautions

Aclene Plus Gel has no known effect on the ability to drive or operate machinery.

Lifestyle Advice

Use non-comedogenic (pore-clogging) and non-irritating skin care products.
Maintain good skin hygiene, but avoid excessive washing or harsh scrubbing.
Do not pick or squeeze acne lesions, as this can worsen acne and lead to scarring.