Medicine Information

Adamax

Name: Adamax
Brand: Adamax
Rating: 4.5 (117 reviews)

Tablet5 mgAntidepressantATC: N06AB

Generic Name

Adam-33

Manufacturer

UniPharma Limited

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
adam 33 5 mg tablet	৳ 1.73	৳ 17.30

Description

Overview of the medicine

Adam-33 is a selective serotonin reuptake inhibitor (SSRI) used to treat various mental health conditions including major depressive disorder, generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder. It works by increasing the levels of serotonin in the brain, a neurotransmitter associated with mood regulation.

Uses & Indications

Major Depressive Disorder

Generalized Anxiety Disorder

Panic Disorder

Obsessive-Compulsive Disorder

Dosage

Adults

Initial dose 5 mg once daily, may be increased to 10-20 mg once daily after several weeks based on response and tolerability. Max dose typically 20 mg/day.

Elderly

Lower starting dose, e.g., 5 mg once daily, with careful titration. Max dose usually 10 mg/day.

Renal_impairment

No dosage adjustment necessary for mild to moderate impairment. Use with caution in severe impairment.

How to Take

Adam-33 tablets should be taken orally once daily, in the morning or evening, with or without food. Swallow the tablet whole with water; do not crush or chew.

Mechanism of Action

Adam-33 selectively inhibits the reuptake of serotonin (5-HT) into the presynaptic neuron, thereby increasing the concentration of 5-HT in the synaptic cleft. This enhanced serotonergic neurotransmission is thought to be responsible for its antidepressant and anxiolytic effects.

Pharmacokinetics

Onset

Therapeutic effects may take 2-4 weeks to become apparent, although some improvement in symptoms may be observed earlier.

Excretion

Excreted predominantly in the urine, with a smaller portion in feces.

Half life

Approximately 24-30 hours, allowing for once-daily dosing.

Absorption

Well absorbed orally, peak plasma concentrations typically achieved within 2-4 hours.

Metabolism

Extensively metabolized in the liver, primarily via CYP2C19 and CYP3A4 enzymes, into inactive metabolites.

Side Effects

Contraindications

Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
Known hypersensitivity to Adam-33 or any excipients of the tablet.
Concomitant use with pimozide.

Drug Interactions

MAOIs

Risk of serotonin syndrome. Avoid concomitant use.

Other Serotonergic Drugs

e.g., Triptans, Tramadol, St. John's Wort. Increased risk of serotonin syndrome.

CYP2C19/CYP3A4 Inhibitors

May increase Adam-33 plasma levels.

Anticoagulants/Antiplatelets

e.g., Warfarin, NSAIDs. Increased risk of bleeding.

Storage

Store at room temperature (below 30°C) in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include nausea, vomiting, dizziness, tremor, somnolence, tachycardia, and in severe cases, seizures and serotonin syndrome. Treatment is symptomatic and supportive. There is no specific antidote.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts may be excreted in breast milk; consult a doctor before breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister30 tablets per box

Shelf Life

3 years from the date of manufacture.

Availability

Available in all pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Patent Expired

Clinical Trials

Clinical trials have demonstrated the efficacy and safety of Adam-33 in the treatment of major depressive disorder, generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder across various patient populations.

Lab Monitoring

Liver function tests (if pre-existing hepatic impairment or signs of dysfunction)
Renal function tests (in severe renal impairment)
Electrolytes (if hyponatremia is suspected)

Doctor Notes

Educate patients on the delayed onset of action and importance of continued treatment.
Monitor for worsening depression and suicidality, especially at the start of treatment or dose changes.
Advise gradual tapering of the dose upon discontinuation to minimize withdrawal symptoms.

Patient Guidelines

Do not stop taking Adam-33 suddenly, as this may lead to withdrawal symptoms. Your doctor will gradually reduce the dose.
Report any new or worsening symptoms of depression, suicidal thoughts, or unusual changes in mood or behavior to your doctor immediately.
Avoid operating machinery or driving until you know how Adam-33 affects you, as it may cause dizziness or drowsiness.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine may cause dizziness, drowsiness, or blurred vision. If you experience these effects, do not drive or operate heavy machinery. Exercise caution until you know how Adam-33 affects your ability to perform such tasks safely.