Medicine Information

Adtrizin

Name: Adtrizin
Brand: Adtrizin
Rating: 4.5 (117 reviews)

Tablet10 mgAntihistamineATC: R06AE07

Generic Name

Cetirizine 10 mg tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
adtrizin 10 mg tablet	৳ 3.00	৳ 30.00

Description

Overview of the medicine

Cetirizine is a potent, selective H1-receptor antagonist indicated for the relief of symptoms associated with allergic conditions such as seasonal and perennial allergic rhinitis, and chronic idiopathic urticaria.

Uses & Indications

Perennial allergic rhinitis

Seasonal allergic rhinitis

Chronic idiopathic urticaria

Allergic conjunctivitis

Dosage

Adults

10 mg once daily, or 5 mg twice daily. Maximum 10 mg/day.

Elderly

Initial dose of 5 mg once daily, adjust based on renal function.

Renal_impairment

Creatinine clearance 31-60 ml/min: 5 mg once daily. Creatinine clearance < 31 ml/min: 5 mg every other day.

How to Take

Adtrizin tablets can be taken orally with or without food. Swallow the tablet whole with a glass of water.

Mechanism of Action

Cetirizine selectively blocks peripheral H1 receptors, thereby inhibiting the effects of histamine which is responsible for allergic symptoms like sneezing, runny nose, and itching. It also has anti-inflammatory properties.

Pharmacokinetics

Onset

20-60 minutes

Excretion

Primarily via urine as unchanged drug; a small amount is excreted in feces.

Half life

Approximately 8-11 hours (adults)

Absorption

Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 1 hour.

Metabolism

Minimal hepatic metabolism; approximately two-thirds of the administered dose is excreted unchanged in urine.

Side Effects

Contraindications

Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
Severe renal impairment (creatinine clearance less than 10 ml/min).
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.

Drug Interactions

Ritonavir

Increases cetirizine plasma levels and prolongs its half-life, potentially increasing adverse effects.

Theophylline

A small decrease in cetirizine clearance has been observed, but the clinical significance is unknown.

Alcohol and CNS Depressants

Concurrent use may enhance CNS depression and impair performance.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, sedation, tachycardia, urinary retention, and tremor. Management should be symptomatic and supportive, including gastric lavage or induced emesis if ingestion is recent. No specific antidote is known.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cetirizine is excreted into breast milk; therefore, caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister (1x10)30 tablets per box (3x10)

Shelf Life

24 months from the date of manufacture

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Cetirizine has undergone extensive clinical trials demonstrating its efficacy and safety for the treatment of various allergic conditions, supporting its widespread use and approval globally.

Lab Monitoring

No specific routine laboratory monitoring is required for patients taking cetirizine.

Doctor Notes

Counsel patients on potential sedation and to avoid alcohol.
Advise on appropriate dosing for renal impairment based on creatinine clearance.
Emphasize consistent daily dosing for optimal allergy management.

Patient Guidelines

Do not exceed the recommended dose.
Avoid alcohol while taking this medicine as it may increase drowsiness.
If drowsiness occurs, avoid driving or operating heavy machinery.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine may cause drowsiness in some individuals. Patients should be advised to exercise caution when driving or operating hazardous machinery until they know how they react to the medication.