Medicine Information

Alargol

Name: Alargol
Brand: Alargol
Rating: 4.5 (117 reviews)

Tablet10 mgAntihistamine, Non-sedatingATC: R06AX13

Generic Name

Loratadine

Manufacturer

Reputable Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
alargol 10 mg tablet	৳ 2.50	৳ 25.00

Description

Overview of the medicine

Alargol 10 mg Tablet contains Loratadine, a non-drowsy antihistamine used to relieve symptoms associated with allergic rhinitis (hay fever) and chronic urticaria (hives). It helps in reducing sneezing, runny nose, itchy or watery eyes, and skin itching.

Uses & Indications

Relief of symptoms associated with allergic rhinitis, such as sneezing, nasal discharge (rhinorrhea), and itching, as well as ocular itching and burning.

Relief of symptoms and signs of chronic urticaria and other allergic dermatological disorders.

Dosage

Adults

10 mg once daily.

Elderly

No dosage adjustment is generally necessary in elderly patients with normal renal and hepatic function.

Renal_impairment

For patients with severe renal impairment (creatinine clearance < 30 mL/min), initial dose should be 10 mg every other day.

How to Take

Alargol tablet can be taken with or without food. Swallow the tablet whole with water.

Mechanism of Action

Loratadine is a tricyclic antihistamine with selective peripheral H1-receptor antagonist activity. It prevents histamine from binding to H1-receptors, thereby inhibiting the symptoms of allergy, without significant central nervous system effects.

Pharmacokinetics

Onset

Within 1-3 hours.

Excretion

Approximately 40% excreted in urine and 42% in feces over 10 days, primarily in the form of conjugated metabolites.

Half life

Loratadine: 8.4 hours (range 3-20 hours). Descarboethoxyloratadine (active metabolite): 28 hours (range 8.8-92 hours).

Absorption

Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.

Metabolism

Extensively metabolized in the liver, primarily by CYP3A4 and CYP2D6, to its major active metabolite, descarboethoxyloratadine.

Side Effects

Contraindications

Hypersensitivity to Loratadine or any component of the formulation.
Known allergy to descarboethoxyloratadine.

Drug Interactions

Ketoconazole, Erythromycin, Cimetidine

May increase plasma concentrations of Loratadine and its active metabolite, though no clinically significant adverse effects have been reported.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, tachycardia, and headache. In the event of an overdose, symptomatic and supportive treatment is recommended. Gastric lavage and activated charcoal may be considered.

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Loratadine and its metabolite pass into breast milk; therefore, caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10's strip)30 tablets (3x10's strips)

Shelf Life

36 months from the date of manufacture.

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA (Directorate General of Drug Administration)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated Loratadine's efficacy and safety in treating allergic rhinitis and chronic urticaria. Post-marketing surveillance continues to monitor its long-term effects.

Lab Monitoring

No specific routine lab monitoring is required for Loratadine.

Doctor Notes

Counsel patients on proper administration and potential for mild somnolence, though rare.
Advise patients to seek medical attention if allergic symptoms persist or worsen despite treatment.
Consider renal/hepatic dose adjustment for severe impairment.

Patient Guidelines

Take Alargol exactly as prescribed by your doctor.
Do not exceed the recommended dose.
Inform your doctor or pharmacist about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Driving Precautions

Alargol is generally non-sedating, but individual responses vary. Exercise caution when driving or operating machinery until you know how this medicine affects you.