Medicine Information

Alclor

Name: Alclor
Brand: Alclor
Rating: 4.5 (117 reviews)

Capsule500 mgAntibiotics, CephalosporinsATC: J01DC04

Generic Name

Cefaclor

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
alclor 500 mg capsule	৳ 40.10	৳ 200.50

Description

Overview of the medicine

Alclor 500 mg capsule contains Cefaclor, a second-generation cephalosporin antibiotic used to treat various bacterial infections including respiratory tract infections, urinary tract infections, and skin and soft tissue infections.

Uses & Indications

Respiratory tract infections (pharyngitis, tonsillitis, sinusitis, bronchitis, pneumonia)

Urinary tract infections (UTIs)

Skin and soft tissue infections

Otitis media

Dosage

Adults

Adults: 250-500 mg every 8 hours. For severe infections, up to 500 mg three times daily. Maximum 4 g/day.

Elderly

Elderly: Usually adult dose, but renal function should be considered. No specific dosage adjustment usually required unless significant renal impairment.

Renal_impairment

Renal impairment: Dosage adjustment may be necessary in severe renal impairment (creatinine clearance <10 mL/min). Consult physician.

How to Take

Alclor capsules can be taken with or without food. However, taking it with food may help reduce gastrointestinal upset in some patients.

Mechanism of Action

Cefaclor inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Rapid.

Excretion

Primarily renal (glomerular filtration and tubular secretion).

Half life

Approximately 0.5-1 hour.

Absorption

Well absorbed orally. Peak plasma concentrations are achieved within 30-60 minutes.

Metabolism

Not extensively metabolized in the body.

Side Effects

Contraindications

Known hypersensitivity to Cefaclor or other cephalosporins.
History of severe hypersensitivity reactions to penicillin.

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding.

Probenecid

May increase cefaclor plasma concentrations by inhibiting renal tubular secretion.

Aminoglycosides

Concurrent use may increase the risk of nephrotoxicity; monitor renal function.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management is primarily supportive. Hemodialysis may be considered in severe cases.

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Cefaclor is excreted in breast milk in small amounts; use with caution in breastfeeding mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per box30 capsules per box

Shelf Life

36 months from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory authorities (e.g., FDA, DGDA)

Patent Status

Generic available

Clinical Trials

Cefaclor has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in treating various bacterial infections. Specific trials for the 'Alclor' brand may exist, but general data for Cefaclor supports its use.

Lab Monitoring

For prolonged therapy, periodic assessment of renal, hepatic, and hematopoietic functions is advisable.
Positive Coombs' tests may occur.

Doctor Notes

Advise patients about potential hypersensitivity reactions, especially those with a history of penicillin allergy.
Emphasize the importance of completing the full course of treatment to prevent resistance.
Consider renal dose adjustment in patients with significant kidney impairment.

Patient Guidelines

Complete the entire course of medication as prescribed, even if symptoms improve.
Do not share this medication with others.
Report any severe or persistent side effects to your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Cefaclor generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or blurred vision, avoid such activities.