Medicine Information

Aldonist

Name: Aldonist
Brand: Aldonist
Rating: 4.5 (117 reviews)

Tablet25 mgPotassium-sparing diureticATC: C03DA01

Generic Name

Spironolactone

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aldonist 25 mg tablet	৳ 45.00	৳ 450.00

Description

Overview of the medicine

Aldonist 25 mg Tablet contains Spironolactone, a potassium-sparing diuretic. It is used to treat conditions such as heart failure, high blood pressure, fluid retention (edema) caused by various conditions like liver cirrhosis or nephrotic syndrome, and primary hyperaldosteronism. It helps the body get rid of excess water and sodium while retaining potassium.

Uses & Indications

Congestive heart failure

Hypertension (as an add-on therapy)

Edema associated with cirrhosis of the liver

Nephrotic syndrome

Primary hyperaldosteronism (diagnosis and treatment)

Hypokalemia (prevention or treatment)

Dosage

Adults

For heart failure, typically 25 mg orally once daily, may be increased to 50 mg daily. For hypertension, 25-100 mg daily. For edema, 25-200 mg daily in divided doses.

Elderly

Initiate with lower doses and titrate carefully, monitoring renal function and electrolytes.

Renal_impairment

Contraindicated in severe renal impairment. Use with caution in moderate impairment, requiring close monitoring of serum potassium and renal function.

How to Take

Oral administration. It is generally recommended to take Aldonist with food to enhance absorption and reduce gastrointestinal upset.

Mechanism of Action

Spironolactone acts as a competitive antagonist of aldosterone at the mineralocorticoid receptors in the distal renal tubules and collecting ducts. This action prevents sodium reabsorption and potassium excretion, leading to increased diuresis and decreased potassium loss.

Pharmacokinetics

Onset

Diuretic effect usually evident within 2-3 days; antihypertensive effect may take 2-4 weeks.

Excretion

Primarily excreted in urine and feces as metabolites.

Half life

Spironolactone (parent drug): 1.3 hours; Active metabolites (Canrenone): 10-35 hours.

Absorption

Rapidly but incompletely absorbed from the gastrointestinal tract; absorption is increased when taken with food.

Metabolism

Extensively metabolized in the liver to active metabolites, primarily canrenone.

Side Effects

Contraindications

Hyperkalemia
Severe renal impairment or acute renal failure
Anuria
Addison's disease
Concomitant use with eplerenone or other potassium-sparing diuretics.

Drug Interactions

Digoxin

Spironolactone may increase serum digoxin concentrations, leading to toxicity.

Lithium

Increased lithium levels due to reduced renal clearance.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

May reduce diuretic and antihypertensive effects; increased risk of renal dysfunction.

ACE inhibitors, Angiotensin Receptor Blockers (ARBs)

Increased risk of hyperkalemia.

Potassium supplements, other potassium-sparing diuretics

Severe hyperkalemia.

Storage

Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include drowsiness, confusion, nausea, vomiting, dizziness, and diarrhea. Hyperkalemia is a major concern, potentially leading to cardiac arrhythmias. Treatment involves discontinuing the drug, gastric lavage, supportive measures, and management of hyperkalemia.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Spironolactone metabolites are excreted in breast milk; use with caution in nursing mothers or consider an alternative.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip; 3 strips per box (30 tablets)

Shelf Life

36 months from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Spironolactone has been extensively studied in clinical trials, particularly for its role in heart failure (e.g., RALES trial), demonstrating significant reductions in mortality and morbidity.

Lab Monitoring

Regularly monitor serum potassium levels, renal function (creatinine, BUN), and electrolytes. Blood pressure monitoring is also crucial.

Doctor Notes

Crucial to monitor serum potassium and renal function (creatinine) at initiation and during dose adjustments, especially in patients at high risk of hyperkalemia.
Advise patients to avoid potassium supplements and potassium-rich foods.
Counsel male patients regarding the possibility of gynecomastia.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not stop taking it without consulting your doctor.
Avoid consuming potassium supplements or high-potassium foods.
Report any signs of hyperkalemia such as muscle weakness, irregular heartbeat, or numbness.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Aldonist may cause dizziness or drowsiness, especially when first starting the medication or adjusting the dose. Exercise caution when driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Maintain a healthy diet, avoiding excessive potassium intake.
Limit alcohol consumption.
Stay hydrated, but follow your doctor's advice on fluid intake if you have heart failure.
Engage in regular light exercise if appropriate.

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