Medicine Information

Alkriz

Name: Alkriz
Brand: Alkriz
Rating: 4.5 (117 reviews)

Capsule250 mgAntibioticATC: J01FA06

Generic Name

Alkriz-250 mg Capsule

Manufacturer

Acme Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
alkriz 250 mg capsule	৳ 750.00	৳ 3,000.00

Description

Overview of the medicine

Alkriz 250 mg Capsule is a macrolide antibiotic used to treat a wide range of bacterial infections, including those of the respiratory tract, skin, and soft tissues. It works by stopping the growth of bacteria.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia, sinusitis)

Skin and soft tissue infections (e.g., folliculitis, cellulitis)

Eradication of Helicobacter pylori in combination therapy for peptic ulcer disease

Dosage

Adults

250-500 mg twice daily for 7-14 days, depending on the type and severity of infection. For H. pylori eradication, typically 500 mg twice daily for 7-14 days as part of a triple therapy regimen.

Elderly

No specific dosage adjustment is usually required unless severe renal impairment is present.

Renal_impairment

For patients with severe renal impairment (creatinine clearance <30 mL/min), the dosage should be reduced by half or the dosing interval prolonged.

How to Take

Alkriz capsules should be taken orally, with or without food. Taking it with food may help reduce gastrointestinal upset.

Mechanism of Action

Alkriz inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby interfering with the translocation of peptides.

Pharmacokinetics

Onset

Onset of antibacterial action is typically within a few hours of administration.

Excretion

Excreted through both renal (approximately 20-40% unchanged drug and metabolite) and biliary/fecal routes (approximately 50-60%).

Half life

The plasma elimination half-life is approximately 3-7 hours.

Absorption

Well absorbed orally, approximately 50% bioavailability. Peak plasma concentrations are reached within 2-3 hours.

Metabolism

Extensively metabolized in the liver, primarily by CYP3A4, to an active 14-hydroxy metabolite which also has antibacterial activity.

Side Effects

Contraindications

Hypersensitivity to macrolide antibiotics or any component of the formulation.
Concomitant administration with cisapride, pimozide, astemizole, terfenadine, or ergot alkaloids (e.g., ergotamine, dihydroergotamine).

Drug Interactions

Digoxin

Increased serum digoxin concentrations.

Warfarin

Increased anticoagulant effect, monitor INR.

Theophylline

Increased serum theophylline concentrations.

Statins (e.g., simvastatin, lovastatin)

Increased risk of myopathy and rhabdomyolysis.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include gastrointestinal upset (nausea, vomiting, diarrhea) and abdominal pain. Treatment involves gastric lavage and symptomatic and supportive care. Hemodialysis and peritoneal dialysis are not effective.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, caution is advised during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per box30 capsules per box

Shelf Life

36 months from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Alkriz (Clarithromycin) has undergone extensive clinical trials demonstrating its efficacy and safety in treating a wide array of bacterial infections across various patient populations.

Lab Monitoring

Liver function tests (LFTs) should be monitored, especially in patients with pre-existing hepatic impairment or during prolonged therapy.
Renal function should be assessed in patients with renal impairment.

Doctor Notes

Assess renal and hepatic function, especially in elderly patients or those with co-morbidities.
Advise patients about potential drug interactions, particularly with warfarin, statins, and medications that prolong the QT interval.
Emphasize the importance of completing the full prescribed course to ensure eradication of infection and prevent resistance.

Patient Guidelines

Complete the full course of treatment as prescribed, even if symptoms improve, to prevent the development of antibiotic resistance.
Do not share this medication with others.
Report any severe or persistent side effects to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Driving Precautions

Alkriz may cause dizziness or visual disturbances in some individuals. Patients should be cautious when driving or operating machinery until they know how the medication affects them.

Lifestyle Advice

Stay well-hydrated throughout the course of treatment.
Avoid alcohol if it aggravates gastrointestinal upset.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Clarith (Incepta)Claribid (Square)Maclar (Beximco)

Global Brand Names

International brand names for this medicine

Incepta Pharmaceuticals Ltd.

Tablet500 mg

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