Medicine Information

Amdin

Name: Amdin
Brand: Amdin
Rating: 4.5 (117 reviews)

Tablet5 mgCalcium Channel Blocker (CCB)ATC: C08CA01

Generic Name

Amlodipine Besilate

Manufacturer

Generic Manufacturer (e.g., Square Pharmaceuticals Ltd.)

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
amdin 5 mg tablet	৳ 4.01	৳ 40.10

Description

Overview of the medicine

Amdin 5 mg tablet contains Amlodipine Besilate, a dihydropyridine calcium channel blocker used to treat high blood pressure (hypertension) and chest pain (angina). It works by relaxing blood vessels, making it easier for the heart to pump blood.

Uses & Indications

Hypertension (high blood pressure)

Chronic stable angina

Vasospastic angina (Prinzmetal's or variant angina)

Dosage

Adults

Initial dose is 5 mg orally once daily, maximum 10 mg once daily. Dosage should be adjusted according to patient's response and tolerance.

Elderly

No specific dose adjustment is typically required, but a lower initial dose of 2.5 mg once daily may be considered.

Renal_impairment

No dose adjustment is required for patients with renal impairment.

How to Take

Take orally with or without food, usually once daily. It should be taken at about the same time each day.

Mechanism of Action

Amlodipine inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. The contractile process of cardiac muscle and vascular smooth muscle depends upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine selectively blocks calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells.

Pharmacokinetics

Onset

Within 6-12 hours for blood pressure reduction.

Excretion

Approximately 60% of the administered dose is excreted in the urine as inactive metabolites, and 20-25% via feces.

Half life

30-50 hours, allowing for once-daily dosing.

Absorption

Well absorbed after oral administration, with peak plasma concentrations occurring 6-12 hours post-dose. Absolute bioavailability is estimated to be 64-90%.

Metabolism

Extensively metabolized in the liver to inactive metabolites via CYP3A4.

Side Effects

Contraindications

Known hypersensitivity to amlodipine or other dihydropyridines.
Severe hypotension.
Cardiogenic shock.
Obstruction of the outflow tract of the left ventricle (e.g., high grade aortic stenosis).
Unstable angina.

Drug Interactions

Ciclosporin

Amlodipine may increase ciclosporin levels; monitor ciclosporin levels.

Simvastatin

Amlodipine may increase simvastatin exposure; limit simvastatin dose to 20 mg/day.

CYP3A4 Inducers (e.g., rifampicin, St. John's Wort)

May decrease amlodipine plasma concentrations, potentially reducing efficacy.

CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, ritonavir)

May increase amlodipine exposure, requiring dose reduction.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia. Management involves active cardiovascular support, including frequent monitoring of cardiac and respiratory function, elevation of extremities, and management of fluid volume and urine output. Intravenous calcium gluconate may be beneficial.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Amlodipine is excreted in human milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets (3x10's)50 tablets (5x10's)

Shelf Life

36 months from the date of manufacture

Availability

Available in pharmacies, hospitals, and clinics

Approval Status

Approved by major regulatory bodies globally (e.g., FDA, DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of amlodipine in hypertension and angina management. Studies often compare amlodipine with other antihypertensive agents and placebo.

Lab Monitoring

Blood pressure monitoring regularly
Electrolyte levels (Potassium)
Renal function (BUN/Creatinine) in patients with severe renal impairment
Liver function tests (if liver impairment is suspected)

Doctor Notes

Start with a low dose (2.5 mg or 5 mg) and titrate based on patient response.
Monitor for peripheral edema, which is a common but usually benign side effect.
Educate patients about adherence to medication and lifestyle modifications for optimal blood pressure control.
Consider interactions with CYP3A4 inhibitors/inducers.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not stop taking amlodipine without consulting your doctor, even if you feel well.
Inform your doctor about all other medications you are taking.
Report any unusual side effects immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Amlodipine may cause dizziness, headache, or fatigue. If these occur, avoid driving or operating heavy machinery until you know how the medicine affects you.