Medicine Information

Amdopril

Name: Amdopril
Brand: Amdopril
Rating: 4.5 (117 reviews)

Tablet5 mgAntihypertensiveATC: C08CA01

Generic Name

Amlodipine Besilate

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
amdopril 5 mg tablet	৳ 21.00	৳ 210.00

Description

Overview of the medicine

Amdopril 5 mg tablet contains Amlodipine Besilate, a long-acting calcium channel blocker primarily used to treat high blood pressure (hypertension) and chest pain (angina). It works by relaxing blood vessels, making it easier for the heart to pump blood, and increasing blood supply to the heart.

Uses & Indications

Hypertension (high blood pressure)

Chronic stable angina

Vasospastic angina (Prinzmetal's angina)

Dosage

Adults

Initial dose is 5 mg once daily. May be increased to a maximum of 10 mg once daily depending on patient response and tolerability.

Elderly

Initial dose of 2.5 mg once daily is recommended.

Renal_impairment

No dosage adjustment is generally required.

How to Take

Take orally once daily, with or without food. It is recommended to take the tablet at about the same time each day.

Mechanism of Action

Amlodipine selectively inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. It acts predominantly on vascular smooth muscle, causing vasodilation and reducing peripheral vascular resistance. In angina, it reduces myocardial oxygen demand by dilating peripheral arterioles and arteries and increases myocardial oxygen delivery by dilating coronary arteries.

Pharmacokinetics

Onset

6-12 hours for antihypertensive effect.

Excretion

Primarily excreted as inactive metabolites in the urine (approximately 60%) and feces (approximately 25%).

Half life

30-50 hours (prolonged in hepatic impairment and elderly).

Absorption

Well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 6-12 hours after oral administration. Bioavailability is 64-90%.

Metabolism

Extensively metabolized in the liver to inactive metabolites (approximately 90%).

Side Effects

Contraindications

Hypersensitivity to Amlodipine, dihydropyridine derivatives, or any component of the formulation.
Severe hypotension.
Cardiogenic shock.
Obstructive outflow tract disease (e.g., severe aortic stenosis).
Hemodynamically unstable heart failure after acute myocardial infarction.

Drug Interactions

Tacrolimus

Increased blood levels of tacrolimus when co-administered with amlodipine.

Simvastatin

Co-administration with Amlodipine may increase simvastatin exposure, increasing the risk of myopathy/rhabdomyolysis. Limit simvastatin dose to 20 mg daily.

Clarithromycin

Increased risk of hypotension and acute kidney injury with concomitant use.

CYP3A4 Inducers (e.g., Rifampicin)

May decrease Amlodipine exposure, potentially reducing its effectiveness.

CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)

May increase Amlodipine exposure, leading to increased risk of hypotension.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia. Management involves close monitoring, symptomatic treatment, and supportive measures, including vasopressors and intravenous fluids. Calcium gluconate may be administered.

Pregnancy & Lactation

Pregnancy: Category C. Use only if the potential benefit outweighs the potential risk to the fetus. Lactation: Amlodipine is excreted in human milk. Discontinue nursing or the drug, taking into account the importance of the drug to the mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets30 tablets100 tablets

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Pharmacies nationwide

Approval Status

Approved by FDA/DGDA

Patent Status

Expired

WHO Essential Medicine

Yes

Clinical Trials

Amlodipine has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of hypertension and angina.

Lab Monitoring

Generally, no specific laboratory monitoring is required. Liver function tests may be considered in patients with hepatic impairment.

Doctor Notes

Monitor blood pressure regularly.
Counsel patients on the importance of adherence and lifestyle modifications.
Caution with co-administration of strong CYP3A4 inhibitors.

Patient Guidelines

Take the medicine as prescribed by your doctor.
Do not stop taking the medicine suddenly without consulting your doctor.
Report any persistent side effects, especially ankle swelling or headache.
Maintain a healthy lifestyle, including diet and exercise.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Amlodipine may cause dizziness, headache, or fatigue, especially at the start of treatment or when the dose is increased. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.