Medicine Information

Amocap

Name: Amocap
Brand: Amocap
Rating: 4.5 (117 reviews)

Capsule500 mgAntibacterial (Penicillin group)ATC: J01CA04

Generic Name

Amoxicillin (as Trihydrate)

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
amocap 500 mg capsule	৳ 6.15	N/A

Description

Overview of the medicine

Amoxicillin is a broad-spectrum penicillin antibiotic used to treat a variety of bacterial infections.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections

Skin and soft tissue infections

Otitis media (middle ear infection)

Sinusitis

Dental abscesses

Dosage

Adults

Typical adult dose is 250 mg to 500 mg every 8 hours, or 500 mg to 875 mg every 12 hours, depending on the severity and type of infection.

Elderly

Similar to adults, but dose adjustment may be necessary in case of impaired renal function.

Renal_impairment

Dose adjustment required based on creatinine clearance. For CrCl <30 mL/min, dosage intervals should be extended.

How to Take

Take orally with a glass of water, with or without food. Complete the full course as prescribed.

Mechanism of Action

It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Approximately 30-60 minutes.

Excretion

Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.

Half life

1 to 1.5 hours in adults with normal renal function.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, not significantly affected by food.

Metabolism

Partially metabolized (10-25%) in the liver to inactive penicilloic acid.

Side Effects

Contraindications

Known hypersensitivity to penicillin antibiotics or any component of Amoxicillin.
History of severe hypersensitivity reaction to other beta-lactam antibiotics (e.g., cephalosporins, carbapenems).

Drug Interactions

Warfarin

May increase anticoagulant effect, requiring INR monitoring and dose adjustment.

Allopurinol

Increased incidence of rash when co-administered.

Methotrexate

May decrease methotrexate clearance, leading to increased toxicity.

Oral contraceptives

May reduce efficacy of oral contraceptives (rare, but advise caution).

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include gastrointestinal disturbances (nausea, vomiting, diarrhea) and fluid-electrolyte imbalance. In very high doses or in patients with impaired renal function, crystalluria and renal impairment may occur. Treatment is symptomatic and supportive; hemodialysis may be used to remove Amoxicillin from circulation.

Pregnancy & Lactation

Pregnancy Category B. Generally considered safe during pregnancy. Excreted in small amounts in breast milk; generally compatible with breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules100 capsules

Shelf Life

Typically 2-3 years, refer to product packaging for exact date.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities

Patent Status

Patent expired, available as generic

WHO Essential Medicine

Yes

Clinical Trials

Amoxicillin has been extensively studied in numerous clinical trials and is a well-established and widely used antibiotic.

Lab Monitoring

Renal function monitoring during prolonged therapy, especially in patients with pre-existing renal impairment.
Liver function tests may be considered in rare cases of hepatic dysfunction.

Doctor Notes

Always inquire about penicillin allergy history before prescribing.
Adjust dosage in patients with renal impairment.
Advise patients to complete the full course of therapy.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Complete the entire course of antibiotics, even if you feel better, to prevent recurrence and antibiotic resistance.
Inform your doctor immediately if you experience any severe allergic reactions (e.g., rash, swelling, difficulty breathing).

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double dose.