Medicine Information

Anadol

Name: Anadol
Brand: Anadol
Rating: 4.5 (117 reviews)

Injection100 mgAnalgesics, Opioid AnalgesicsATC: N02AX02

Generic Name

Tramadol Hydrochloride

Manufacturer

Example Pharma Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
anadol 100 mg injection	৳ 20.14	N/A

Description

Overview of the medicine

Anadol 100 mg Injection contains Tramadol Hydrochloride, which is a synthetic opioid analgesic used for the relief of moderate to severe pain. It acts on opioid receptors in the brain and spinal cord to reduce the perception of pain. It is often used in hospital settings for post-operative pain or acute severe pain.

Uses & Indications

Moderate to severe acute and chronic pain

Post-operative pain

Cancer pain

Dosage

Adults

Typically, 50-100 mg IV or IM every 4-6 hours as needed, not to exceed 400 mg/day.

Elderly

No specific dose adjustment needed unless severe renal or hepatic impairment. Doses may be reduced for patients over 75 years.

Renal_impairment

Reduce dose and/or increase dosing interval in patients with creatinine clearance less than 30 mL/min (e.g., 50-100 mg every 12 hours).

How to Take

Administer slowly intravenously over 2-3 minutes or intramuscularly. Ensure proper aseptic technique.

Mechanism of Action

Tramadol is a centrally acting analgesic. It binds to μ-opioid receptors in the central nervous system. Additionally, it inhibits the reuptake of norepinephrine and serotonin, which contributes to its analgesic effect.

Pharmacokinetics

Onset

Within 30-60 minutes after parenteral administration.

Excretion

Primarily excreted renally (approximately 90%) and about 10% in feces.

Half life

Approximately 6 hours for tramadol and 7-9 hours for the active metabolite O-desmethyltramadol (M1).

Absorption

Rapid and almost complete absorption after intramuscular administration; high bioavailability (70-80%) after oral administration.

Metabolism

Extensively metabolized in the liver by CYP2D6 and CYP3A4 enzymes to O-desmethyltramadol (M1) and other inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to tramadol or any component of the formulation
Acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids, or psychotropic drugs
Concomitant use with MAO inhibitors or within 14 days of discontinuing them
Epilepsy not controlled by treatment

Drug Interactions

Quinidine

Increases tramadol levels by inhibiting CYP2D6 metabolism.

Carbamazepine

Significantly decreases tramadol plasma concentrations, reducing analgesic effect.

MAO Inhibitors

Increased risk of seizures and serotonin syndrome.

SSRIs/SNRIs/TCAs

Increased risk of serotonin syndrome and seizures.

CNS Depressants (e.g., benzodiazepines, alcohol)

Additive CNS depression, increased risk of respiratory depression, profound sedation, coma, and death.

Storage

Store below 30°C in a dry place, away from light. Do not freeze.

Overdose

Symptoms of overdose include respiratory depression, somnolence, coma, seizures, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and possibly death. Treatment involves maintaining a patent airway, providing ventilatory support, and administering opioid antagonists like naloxone.

Pregnancy & Lactation

Pregnancy Category C. Not recommended for use during pregnancy, especially near term, due to potential for neonatal opioid withdrawal syndrome. Tramadol is excreted in breast milk; therefore, it is not recommended during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 ampoules per box10 ampoules per box

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Hospitals, Pharmacies

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have demonstrated tramadol's efficacy and safety for moderate to severe pain. Ongoing research explores its use in neuropathic pain and chronic conditions.

Lab Monitoring

Monitor renal and hepatic function during long-term therapy.
Monitor for signs of respiratory depression and CNS depression.

Doctor Notes

Assess patient's pain level and risk factors for opioid abuse before prescribing.
Start with the lowest effective dose and titrate slowly.
Monitor for signs of respiratory depression, especially during initiation or dose escalation.

Patient Guidelines

Do not exceed the prescribed dose.
Avoid alcohol while taking this medicine.
Report any severe side effects immediately.
Do not stop taking the medicine suddenly without consulting your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to catch up.