Medicine Information

Anaflex Max

Name: Anaflex Max
Brand: Anaflex Max
Rating: 4.5 (117 reviews)

Tablet500 mgNon-steroidal Anti-inflammatory Drug (NSAID)ATC: M01AE02

Generic Name

Naproxen Sodium

Manufacturer

ACI Limited

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
anaflex max 500 mg tablet	৳ 21.00	৳ 210.00

Description

Overview of the medicine

Anaflex Max 500 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by various conditions like arthritis, menstrual cramps, and acute gout.

Uses & Indications

Rheumatoid arthritis

Osteoarthritis

Ankylosing spondylitis

Juvenile arthritis

Tendinitis

Bursitis

Acute gout

Menstrual cramps

Mild to moderate pain

Dosage

Adults

Typically 500 mg initially, followed by 250 mg every 6-8 hours, or 500 mg twice daily. Max 1250 mg/day.

Elderly

Lower doses may be required due to increased risk of side effects. Max 750 mg/day.

Renal_impairment

Reduced dosage, careful monitoring; generally not recommended for severe impairment.

How to Take

Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.

Mechanism of Action

Naproxen Sodium inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing inflammation, pain, and fever.

Pharmacokinetics

Onset

Pain relief usually within 1 hour.

Excretion

Mainly excreted in the urine (95%) as naproxen, 6-O-desmethylnaproxen, and their conjugates.

Half life

Approximately 12-17 hours.

Absorption

Well absorbed from the gastrointestinal tract, peak plasma levels reached in 1-4 hours.

Metabolism

Primarily metabolized in the liver by the cytochrome P450 system (CYP2C9) to 6-O-desmethylnaproxen.

Side Effects

Contraindications

Hypersensitivity to naproxen or other NSAIDs
Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Active gastrointestinal bleeding or peptic ulcer
Severe heart failure
Third trimester of pregnancy
Severe renal or hepatic impairment

Drug Interactions

Lithium

Increased lithium plasma levels.

Methotrexate

Increased methotrexate toxicity.

Diuretics and ACE inhibitors

Reduced antihypertensive effect and increased risk of renal impairment.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Other NSAIDs or corticosteroids

Increased risk of gastrointestinal side effects.

Storage

Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.

Overdose

Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care, gastric lavage, activated charcoal, and monitoring of vital signs.

Pregnancy & Lactation

Pregnancy Category C (D in 3rd trimester or near delivery). Avoid in late pregnancy due to risk of premature closure of ductus arteriosus. Use with caution during lactation; small amounts are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets30 tablets

Shelf Life

24-36 months

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies

Patent Status

Expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of Naproxen Sodium for its indicated uses. Ongoing post-marketing surveillance continues to monitor its effects.

Lab Monitoring

Complete blood count (CBC)
Liver function tests (LFTs)
Kidney function tests (KFTs)
Blood pressure monitoring

Doctor Notes

Assess cardiovascular risk factors before prescribing.
Monitor renal function, blood pressure, and CBC periodically during long-term therapy.
Consider proton pump inhibitor co-therapy for patients at high GI risk.
Advise patients on signs of serious adverse events.

Patient Guidelines

Do not exceed the recommended dose.
Take with food or milk to reduce stomach upset.
Report any signs of gastrointestinal bleeding (black, tarry stools; coffee-ground vomit) immediately.
Avoid alcohol while taking this medicine.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.