Medicine Information

Ancor-A

Name: Ancor-A
Brand: Ancor-A
Rating: 4.5 (117 reviews)

Tablet25 mgBeta-blockerATC: C07AB03

Generic Name

Atenolol

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ancor a 25 mg tablet	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Ancor-A 25 mg Tablet contains Atenolol, a cardioselective beta-adrenergic blocker, primarily used to treat high blood pressure, angina pectoris, and certain heart rhythm disorders.

Uses & Indications

Hypertension (High Blood Pressure)

Angina Pectoris

Cardiac Arrhythmias (e.g., supraventricular tachycardias)

Early intervention in Acute Myocardial Infarction

Prophylaxis of Migraine

Dosage

Adults

Hypertension: Initially 25-50 mg once daily, adjusted up to 100 mg daily based on response. Angina: 50-100 mg once daily. Arrhythmias: 50-100 mg once daily. Myocardial Infarction: 50 mg daily or 100 mg daily as directed by physician.

Elderly

Lower starting doses (e.g., 25 mg daily) are recommended, with careful titration, especially in those with impaired renal function.

Renal_impairment

Dose adjustment necessary based on creatinine clearance: CrCl 15-35 mL/min: 50 mg daily; CrCl < 15 mL/min: 25 mg daily or 50 mg every other day. Hemodialysis patients: 25-50 mg after each dialysis.

How to Take

Take Ancor-A 25 mg Tablet orally, usually once daily, with or without food. Swallow the tablet whole with water. Do not crush, chew, or break it.

Mechanism of Action

Atenolol selectively blocks beta-1 adrenergic receptors, predominantly in the heart. This reduces heart rate, myocardial contractility, and blood pressure, leading to decreased oxygen demand by the heart.

Pharmacokinetics

Onset

Oral: 1 hour; maximum effect in 2-4 hours.

Excretion

Primarily excreted unchanged via the kidneys.

Half life

Approximately 6-7 hours, can be prolonged in renal impairment.

Absorption

Incompletely absorbed (approximately 50-60%) from the gastrointestinal tract. Peak plasma concentrations are reached within 2-4 hours.

Metabolism

Not significantly metabolized by the liver.

Side Effects

Contraindications

Sinus bradycardia (heart rate < 45 bpm)
Second or third-degree heart block
Cardiogenic shock
Decompensated heart failure
Sick sinus syndrome
Severe peripheral arterial disease
Metabolic acidosis
Untreated phaeochromocytoma
Severe asthma or chronic obstructive pulmonary disease (COPD)

Drug Interactions

Clonidine

If clonidine is withdrawn while the patient is receiving Atenolol, there may be a risk of rebound hypertension. If both drugs are co-administered, Clonidine should be discontinued gradually over several days, and Atenolol should be stopped a few days before.

Insulin or Oral Hypoglycemics

Atenolol may mask the symptoms of hypoglycemia (e.g., tachycardia).

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)

May reduce the antihypertensive effect of Atenolol.

Verapamil or Diltiazem (calcium channel blockers)

Increased risk of bradycardia, heart block, and hypotension. Avoid concomitant use.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include severe bradycardia, hypotension, acute cardiac failure, bronchospasm. Management is symptomatic and supportive. Administer atropine for bradycardia, glucagon, intravenous fluids, and vasopressors as needed. Hemodialysis can be used to remove Atenolol from circulation.

Pregnancy & Lactation

Pregnancy Category D. Atenolol may cause fetal harm when administered to a pregnant woman, including intrauterine growth restriction, bradycardia, and hypoglycemia in the neonate. Excreted in breast milk; potential for adverse effects in nursing infants (e.g., bradycardia, hypoglycemia). Use with caution and only if the potential benefit outweighs the risk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets per box

Shelf Life

36 months from manufacturing date

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities worldwide

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of Atenolol in the management of hypertension, angina, and cardiac arrhythmias.

Lab Monitoring

Blood pressure
Heart rate
Renal function (serum creatinine, BUN)
Blood glucose (in diabetic patients)

Doctor Notes

Caution should be exercised in patients with diabetes, bronchial asthma, or peripheral vascular disease.
Regular monitoring of blood pressure and heart rate is essential.
Withdrawal should be gradual to avoid rebound effects.

Patient Guidelines

Do not stop taking the medicine abruptly without consulting your doctor.
Report any unusual or severe side effects to your physician.
Take the medicine consistently at the same time each day.
Monitor your blood pressure regularly at home if advised.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Atenolol may cause dizziness or fatigue, especially at the start of treatment. Patients should be warned not to drive or operate machinery until their response to treatment is known.

Lifestyle Advice

Maintain a healthy lifestyle with regular exercise.
Follow a low-sodium diet and limit saturated fats.
Avoid excessive alcohol consumption and quit smoking.
Manage stress effectively.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Cardilol (Square Pharmaceuticals Ltd.)Aten (Incepta Pharmaceuticals Ltd.)Atelon (Acme Laboratories Ltd.)Ateno (Renata Limited)

Global Brand Names

International brand names for this medicine

Incepta Pharmaceuticals Ltd.

Oral Solution / Syrup670 mg/ml (10g/15ml)

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