Medicine Information

Antipro

Name: Antipro
Brand: Antipro
Rating: 4.5 (117 reviews)

Oral Suspension200 mg/5 mLAnti-amoebic, Anti-protozoal, AntibacterialATC: P01AB01

Generic Name

Metronidazole

Manufacturer

XYZ Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
antipro 200 mg suspension	৳ 29.89	N/A

Description

Overview of the medicine

Antipro 200 mg Suspension is an antibiotic and antiprotozoal medication primarily used to treat various infections caused by anaerobic bacteria and certain parasites. It is effective against infections of the gastrointestinal tract, skin, joints, gynecological infections, and sexually transmitted diseases like trichomoniasis.

Uses & Indications

Treatment of anaerobic bacterial infections (e.g., intra-abdominal, skin and soft tissue, gynecological, lower respiratory tract, bone and joint infections)

Treatment of amoebiasis (intestinal and extra-intestinal)

Treatment of giardiasis

Treatment of trichomoniasis

Prophylaxis of post-operative infections

Dosage

Adults

Amoebiasis: 400-800 mg three times daily for 5-10 days. Giardiasis: 250 mg three times daily for 5-7 days. Anaerobic infections: 400 mg three times daily for 7 days. Doses should be adjusted based on infection severity and patient response.

Elderly

No specific dose adjustment is generally required, but caution should be exercised, and renal/hepatic function should be monitored.

Renal_impairment

In severe renal impairment (CrCl <10 mL/min), dosage reduction to half of the usual dose may be considered. No adjustment needed for mild to moderate impairment.

How to Take

Take Antipro 200 mg Suspension orally, preferably with or after food, to minimize gastrointestinal upset. Shake the bottle well before each use. Use the provided measuring cup or spoon for accurate dosing.

Mechanism of Action

Metronidazole enters the microbial cells by passive diffusion. Once inside, its nitro group is reduced by electron transport proteins (ferrodoxin) present in anaerobic bacteria and protozoa. This reduction process produces highly reactive cytotoxic compounds that damage microbial DNA and other macromolecules, leading to cell death.

Pharmacokinetics

Onset

Clinical effects usually within 24-48 hours.

Excretion

Mainly excreted in urine (60-80% of the dose) as unchanged drug and metabolites; a small amount is excreted in feces.

Half life

Approximately 8 hours (range 6-12 hours).

Absorption

Rapidly and completely absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours.

Metabolism

Extensively metabolized in the liver, primarily by oxidation, to form hydroxylated and glucuronidated metabolites.

Side Effects

Contraindications

Hypersensitivity to metronidazole or other nitroimidazole derivatives
First trimester of pregnancy (relative contraindication)
Active central nervous system (CNS) disease
Blood dyscrasias

Drug Interactions

Alcohol

Disulfiram-like reaction (nausea, vomiting, flushing, tachycardia) when consumed with or shortly after metronidazole. Avoid alcohol during treatment and for at least 72 hours after.

Lithium

May increase serum lithium levels, leading to lithium toxicity.

Warfarin

Potentiates the anticoagulant effect of warfarin and other oral anticoagulants, increasing the risk of bleeding. Close monitoring of INR/PT is required.

Cimetidine

May prolong the half-life of metronidazole by inhibiting its metabolism.

Phenobarbital/Phenytoin

May reduce metronidazole effectiveness by increasing its metabolism.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Do not freeze.

Overdose

Symptoms of overdose may include nausea, vomiting, ataxia, and mild disorientation. There is no specific antidote. Treatment is symptomatic and supportive. Gastric lavage may be considered within the first few hours of ingestion.

Pregnancy & Lactation

Pregnancy Category B. While studies in animals have not shown harm, human data are limited, especially in the first trimester. Use only if clearly needed after careful consideration of risks and benefits. Metronidazole is excreted into breast milk; therefore, either nursing should be interrupted or the drug should be discontinued during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 mL bottle100 mL bottle

Shelf Life

Typically 24-36 months from the date of manufacture when stored properly. Once opened, use within 14 days.

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA

Patent Status

Generic drug, patent expired

WHO Essential Medicine

Yes

Clinical Trials

Metronidazole has undergone extensive clinical trials since its introduction, establishing its efficacy and safety in treating various anaerobic and protozoal infections. Ongoing research focuses on optimizing dosages and exploring new applications.

Lab Monitoring

Complete blood count (CBC) for prolonged therapy (>10 days) or high doses.
Liver function tests (LFTs) in patients with hepatic impairment or prolonged therapy.
Renal function tests if renal impairment is suspected.

Doctor Notes

Advise patients to complete the full course to prevent resistance and recurrence.
Emphasize strict alcohol avoidance due to disulfiram-like reaction.
Monitor for neurological symptoms, especially with prolonged therapy.
Caution in patients with severe hepatic impairment; dose reduction may be necessary.

Patient Guidelines

Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Do not consume alcohol or alcohol-containing products during treatment and for at least 3 days after stopping.
Take with food to minimize stomach upset.
Inform your doctor about any unusual side effects or if your symptoms do not improve.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Antipro 200 mg Suspension may cause dizziness or confusion. If you experience these symptoms, avoid driving or operating machinery.

Lifestyle Advice

Avoid alcohol completely during treatment and for at least 72 hours afterwards.
Maintain good hydration.
Practice good hygiene to prevent reinfection, especially in parasitic infections.