Medicine Information

Anxino

Name: Anxino
Brand: Anxino
Rating: 4.5 (117 reviews)

Tablet0.5 mgAnxiolytics, Hypnotics & SedativesATC: N05BA12

Generic Name

Alprazolam

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
anxino 05 mg tablet	৳ 5.00	৳ 50.00

Description

Overview of the medicine

Anxino 0.5 mg Tablet contains Alprazolam, a benzodiazepine primarily used for the short-term management of anxiety disorders, panic disorders, and anxiety associated with depression. It works by enhancing the activity of certain neurotransmitters in the brain.

Uses & Indications

Management of anxiety disorders

Short-term relief of the symptoms of anxiety

Management of panic disorder, with or without agoraphobia

Anxiety associated with depression

Dosage

Adults

Generalized Anxiety Disorder: Initially 0.25-0.5 mg orally three times daily. Max: 4 mg/day. Panic Disorder: Initially 0.5 mg orally three times daily. Max: 10 mg/day.

Elderly

Initially 0.25 mg two or three times daily, adjusted as tolerated.

Renal_impairment

Use with caution. No specific dose adjustment guidelines are available for mild to moderate impairment. Avoid in severe impairment.

How to Take

Take orally with or without food. Do not crush, chew, or break extended-release tablets.

Mechanism of Action

Alprazolam binds to specific benzodiazepine receptors on GABA-A receptors in the central nervous system, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA), leading to anxiolytic, sedative, hypnotic, and anticonvulsant actions.

Pharmacokinetics

Onset

15-30 minutes

Excretion

Mainly excreted in the urine as metabolites.

Half life

Approximately 11-15 hours (range 6-27 hours)

Absorption

Rapidly and well absorbed after oral administration. Peak plasma concentrations are reached within 1-2 hours.

Metabolism

Extensively metabolized in the liver primarily by cytochrome P450 3A4 (CYP3A4) to an active alpha-hydroxyalprazolam and an inactive benzophenone derivative.

Side Effects

Contraindications

Hypersensitivity to alprazolam or other benzodiazepines
Acute narrow-angle glaucoma
Concomitant use with potent CYP3A inhibitors (e.g., ketoconazole, itraconazole)

Drug Interactions

Opioids

Increased risk of respiratory depression, profound sedation, coma, and death. Avoid concomitant use or limit dosage and duration.

CNS Depressants (e.g., Alcohol, Antidepressants, Antihistamines)

Additive CNS depressant effects, increasing drowsiness and sedation.

CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole, Grapefruit juice)

Can significantly increase alprazolam plasma concentrations, potentially leading to increased side effects and toxicity.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Treatment is primarily supportive. Flumazenil, a benzodiazepine receptor antagonist, may be used to reverse effects but can precipitate acute withdrawal in dependent patients.

Pregnancy & Lactation

Pregnancy Category D. Alprazolam can cause fetal harm when administered to a pregnant woman. Avoid during pregnancy. It is excreted in human milk and may cause sedation in the infant; discontinue nursing or the drug.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets50 tablets100 tablets

Shelf Life

3 years from manufacturing date

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Generic available

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of Alprazolam for its approved indications, especially in the short-term treatment of anxiety and panic disorders.

Lab Monitoring

No routine lab monitoring is required for short-term use. For prolonged use, periodic assessment of liver function tests and blood counts may be considered.

Doctor Notes

Prescribe for the shortest effective duration to minimize the risk of dependence and withdrawal.
Counsel patients on the risks of concomitant use with opioids and alcohol.
Monitor for signs of misuse, abuse, and dependence, especially in patients with a history of substance abuse.

Patient Guidelines

Do not stop taking Anxino abruptly, as this can lead to severe withdrawal symptoms. Your doctor will gradually reduce your dose.
Avoid alcohol and other central nervous system depressants while taking this medicine.
Do not drive or operate heavy machinery until you know how this medicine affects you.
Report any new or worsening side effects, especially unusual changes in mood or behavior, to your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once.

Driving Precautions

Anxino can cause drowsiness, dizziness, and impaired coordination. Do not drive or operate hazardous machinery until you are certain this medicine does not affect your ability to perform such activities safely.