Medicine Information

Apozyth

Name: Apozyth
Brand: Apozyth
Rating: 4.5 (117 reviews)

Oral Suspension200 mg/5 mlMacrolide AntibioticATC: J01FA10

Generic Name

Azithromycin

Manufacturer

Acme Pharmaceuticals

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
apozyth 200 mg suspension	৳ 130.00	N/A

Description

Overview of the medicine

Apozyth 200 mg Suspension is a macrolide antibiotic used to treat various bacterial infections in children and adults.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Skin and soft tissue infections

Otitis media (middle ear infection)

Pharyngitis/tonsillitis (streptococcal)

Sexually transmitted infections (e.g., chlamydia)

Dosage

Adults

500 mg (12.5 ml of suspension) as a single dose on day 1, followed by 250 mg (6.25 ml) once daily for 4 days, or 500 mg (12.5 ml) once daily for 3 days.

Elderly

No dosage adjustment is generally required for elderly patients.

Pediatric

10 mg/kg once daily for 3 days, or 10 mg/kg on day 1 followed by 5 mg/kg once daily on days 2-5 (maximum 500 mg/day).

Renal_impairment

No dosage adjustment is necessary for patients with mild to moderate renal impairment. Use with caution in severe impairment.

How to Take

Shake the bottle well before each use. Administer orally with the provided measuring device. Can be taken with or without food.

Mechanism of Action

Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby interfering with mRNA translation.

Pharmacokinetics

Onset

Within 2-3 hours of administration.

Excretion

Mainly excreted unchanged in bile; a small portion is excreted via urine.

Half life

Approximately 2-4 days (due to extensive tissue distribution and slow release).

Absorption

Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37% and is reduced by food.

Metabolism

Primarily hepatic, but not via the cytochrome P450 system to a significant extent.

Side Effects

Contraindications

Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.

Drug Interactions

Digoxin

Increased plasma digoxin levels. Monitor digoxin levels.

Warfarin

Increased anticoagulant effects. Monitor PT/INR.

Nelfinavir

Increased azithromycin concentrations. Monitor for azithromycin side effects.

Cyclosporine

Increased cyclosporine levels. Monitor cyclosporine levels.

Antacids (containing aluminum or magnesium)

Decreased peak plasma levels of azithromycin when co-administered. Take azithromycin at least 1 hour before or 2 hours after antacids.

Storage

Store the dry powder below 30°C. Protect from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C) and discard after 5-10 days.

Overdose

In case of overdose, symptoms are typically exaggerated side effects such as severe nausea, vomiting, and diarrhea. Gastric lavage and general supportive measures are recommended.

Pregnancy & Lactation

Pregnancy Category B. Azithromycin should be used during pregnancy only if clearly needed. It is excreted in human milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

15 ml bottle30 ml bottle60 ml bottle

Shelf Life

Unreconstituted powder: 2-3 years. Reconstituted suspension: 5-10 days when stored as directed.

Availability

Available in pharmacies and hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of azithromycin for its approved indications. Ongoing research explores new applications and formulations.

Lab Monitoring

Liver function tests (especially with prolonged use or pre-existing hepatic impairment)
Renal function tests (if severe renal impairment)

Doctor Notes

Emphasize the importance of completing the full antibiotic course to prevent resistance.
Counsel patients on potential gastrointestinal side effects and advise taking with food if bothersome.
Be aware of potential drug interactions, especially with warfarin and digoxin.

Patient Guidelines

Complete the full course of medication, even if symptoms improve.
Do not share your medication with others.
Shake the suspension well before each dose.
Report any severe or persistent side effects to your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.