Medicine Information

Arilol

Name: Arilol
Brand: Arilol
Rating: 4.5 (117 reviews)

Tablet25 mgBeta-adrenoceptor BlockerATC: C07AB

Generic Name

Arilol

Manufacturer

Medix Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
arilol 25 mg tablet	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Arilol 25 mg Tablet is a cardioselective beta-adrenoceptor blocker used to treat various cardiovascular conditions, including hypertension, angina pectoris, and certain cardiac arrhythmias. It works by blocking beta-receptors in the heart, leading to a reduction in heart rate and blood pressure.

Uses & Indications

Management of hypertension (high blood pressure)

Prophylaxis of angina pectoris (chest pain)

Management of cardiac arrhythmias

Migraine prophylaxis

Dosage

Adults

Hypertension: Initially 25 mg once daily, may be increased to 50 mg if necessary after 1-2 weeks. Angina: 25-50 mg once daily. Arrhythmias: 25-50 mg once daily.

Elderly

Start with a lower dose, typically 12.5 mg once daily. Adjust dose carefully based on response and renal function.

Renal_impairment

Dose adjustment required. For CrCl 15-35 mL/min, 25 mg every other day. For CrCl <15 mL/min, 25 mg every four days.

How to Take

Take orally, with or without food, preferably at the same time each day. Do not crush or chew the tablet; swallow whole with water.

Mechanism of Action

Arilol selectively blocks beta-1 adrenergic receptors, primarily located in the heart. This reduces heart rate, myocardial contractility, and cardiac output, leading to a decrease in blood pressure. It also reduces renin release from the kidneys.

Pharmacokinetics

Onset

Within 1-2 hours

Excretion

Mainly via renal excretion (approximately 85-100% unchanged drug within 24 hours).

Half life

Approximately 6-9 hours

Absorption

Rapid and complete absorption from the gastrointestinal tract (approximately 80-90%). Bioavailability is about 50-60% due to first-pass metabolism.

Metabolism

Minimal hepatic metabolism (less than 10%), primarily excreted unchanged.

Side Effects

Contraindications

Second or third-degree heart block (without a pacemaker)
Cardiogenic shock
Uncontrolled heart failure
Severe bradycardia
Sick sinus syndrome (without a pacemaker)
Severe peripheral arterial disease

Drug Interactions

Digoxin

May increase the risk of bradycardia.

Clonidine

Withdrawal of clonidine may cause rebound hypertension, especially if a beta-blocker is also withdrawn abruptly.

NSAIDs (e.g., ibuprofen)

May reduce the hypotensive effect of beta-blockers.

Calcium Channel Blockers (e.g., verapamil, diltiazem)

Increased risk of bradycardia, hypotension, and heart block. Careful monitoring is required.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include severe bradycardia, hypotension, acute heart failure, and bronchospasm. Management involves symptomatic and supportive treatment, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm.

Pregnancy & Lactation

Pregnancy Category C. Arilol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets60 tablets

Shelf Life

36 months from manufacturing date

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Clinical trials have demonstrated Arilol's efficacy and safety in reducing blood pressure and managing angina. Ongoing studies explore its potential in other cardiovascular applications.

Lab Monitoring

Blood pressure
Heart rate
Renal function tests (especially in elderly or renally impaired patients)
Blood glucose (in diabetic patients)

Doctor Notes

Advise patients on gradual withdrawal to avoid rebound effects.
Monitor heart rate and blood pressure regularly.
Caution in patients with obstructive airway disease or poorly controlled diabetes.

Patient Guidelines

Do not stop the medication abruptly without consulting your doctor.
Inform your doctor about any new or worsening symptoms.
Take your medication at the same time each day.
Avoid driving or operating heavy machinery until you know how Arilol affects you.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Arilol may cause dizziness or fatigue, especially at the start of treatment. Patients should be cautioned against driving or operating machinery until they know how Arilol affects their ability to perform such activities.