Medicine Information

Aristomox-CV

Name: Aristomox-CV
Brand: Aristomox-CV
Rating: 4.5 (117 reviews)

TabletAmoxicillin 250 mg / Clavulanic Acid 125 mgAntibiotics, PenicillinsATC: J01CR02

Generic Name

Amoxicillin Trihydrate & Clavulanate Potassium 250 mg/125 mg Tablet

Manufacturer

Aristopharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aristomox cv 250 mg tablet	৳ 25.00	৳ 150.00

Description

Overview of the medicine

Aristomox-CV is a combination antibiotic containing Amoxicillin, a penicillin-type antibiotic, and Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat various bacterial infections that are resistant to Amoxicillin alone.

Uses & Indications

Upper and lower respiratory tract infections (e.g., sinusitis, bronchitis, pneumonia)

Urinary tract infections

Skin and soft tissue infections

Otitis media

Bone and joint infections

Dosage

Adults

Typically 250 mg/125 mg tablet every 8 hours or 500 mg/125 mg tablet every 12 hours, depending on severity. For severe infections, higher doses may be prescribed.

Elderly

Dosage should be adjusted based on renal function, similar to adults.

Renal_impairment

Dosage reduction is necessary. For mild to moderate impairment, 250 mg/125 mg every 12 hours. For severe impairment, not recommended or requires significant dose reduction and monitoring.

How to Take

Take orally at the start of a meal to minimize potential gastrointestinal intolerance. Swallow the tablet whole with water.

Mechanism of Action

Amoxicillin inhibits bacterial cell wall synthesis. Clavulanic acid irreversibly binds to and inactivates beta-lactamase enzymes produced by bacteria, thereby extending Amoxicillin's spectrum of activity.

Pharmacokinetics

Onset

Peak plasma concentrations reached within 1-2 hours.

Excretion

Primarily excreted unchanged in the urine via renal tubular secretion and glomerular filtration.

Half life

Amoxicillin: approximately 1 hour; Clavulanic Acid: approximately 1 hour.

Absorption

Well absorbed from the gastrointestinal tract, especially when taken at the start of a meal.

Metabolism

Amoxicillin is minimally metabolized; Clavulanic acid is extensively metabolized.

Side Effects

Contraindications

History of hypersensitivity to penicillin or other beta-lactam antibiotics.
History of Amoxicillin/Clavulanate-associated jaundice or hepatic dysfunction.
Severe renal impairment (without dose adjustment).

Drug Interactions

Warfarin

May increase the anticoagulant effect, requiring close INR monitoring.

Allopurinol

Increased risk of skin rash.

Methotrexate

May increase methotrexate toxicity due to reduced renal excretion.

Oral Contraceptives

May reduce the efficacy of oral contraceptives.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

May cause gastrointestinal symptoms (nausea, vomiting, diarrhea), electrolyte imbalance, and convulsions. Treatment is symptomatic and supportive; hemodialysis may be used to remove the drug.

Pregnancy & Lactation

Generally considered safe for use during pregnancy when clearly needed, but consult a doctor. Excreted in breast milk, use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 tablets3 x 10 tablets

Shelf Life

Typically 24 months

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied and widely used for various bacterial infections. Ongoing research focuses on resistance patterns and new formulations.

Lab Monitoring

Liver function tests (especially with prolonged use or in patients with hepatic impairment).
Renal function tests (for patients with renal impairment).
Complete blood count (rarely, during prolonged therapy).

Doctor Notes

Advise patients on the importance of completing the full course to prevent resistance.
Caution in patients with a history of liver or kidney disease; adjust dosage accordingly.

Patient Guidelines

Complete the full course of medication, even if symptoms improve, to prevent resistance.
Take with food to reduce stomach upset.
Report any severe diarrhea or allergic reactions immediately to a doctor.