Axant
Generic Name
Escitalopram Oxalate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| axant 10 mg tablet | ৳ 4.50 | N/A |
Description
Overview of the medicine
Escitalopram is an antidepressant used to treat major depressive disorder, generalized anxiety disorder, panic disorder, social anxiety disorder, and obsessive-compulsive disorder.
Uses & Indications
Dosage
Adults
Initial 10 mg once daily, may be increased to 20 mg/day after at least one week. Maximum 20 mg/day.
Elderly
Initial 5 mg once daily, maximum 10 mg/day.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Oral, once daily, with or without food.
Mechanism of Action
It selectively inhibits the reuptake of serotonin (5-HT) in the presynaptic neuron, thereby increasing the concentration of serotonin in the synaptic cleft and enhancing its neurotransmission.
Pharmacokinetics
Onset
Initial effects may be seen in 1-2 weeks, full therapeutic effect in 4-6 weeks.
Excretion
Excreted renally and hepatically.
Half life
Approximately 27-32 hours.
Absorption
Well absorbed orally, not significantly affected by food. Peak plasma levels usually in 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2C19, to inactive metabolites.
Side Effects
Contraindications
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors)
- Known hypersensitivity to escitalopram or citalopram
Drug Interactions
MAOIs
Increased risk of serotonin syndrome.
Warfarin
Increased risk of bleeding.
Other SSRIs, TCAs, Triptans, Fentanyl, Lithium, St. John's Wort
Increased risk of serotonin syndrome.
Storage
Store below 30°C, protected from light and moisture.
Overdose
Symptoms include dizziness, tremor, nausea, vomiting, somnolence, tachycardia, ECG changes. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to fetus. Excreted in breast milk, caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent expired, generic versions available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated its efficacy and safety across various indications.
Lab Monitoring
- No routine lab monitoring generally required.
- May monitor serum sodium in elderly or those on diuretics.
Doctor Notes
- Gradual dose reduction is required upon discontinuation to prevent withdrawal symptoms.
- Monitor patients for worsening depression, suicidal thoughts, or unusual changes in behavior, especially at the initiation of therapy or during dose adjustments.
Patient Guidelines
- Take as prescribed, do not stop abruptly.
- Inform your doctor of any side effects.
- It may take several weeks for the full therapeutic effect to be observed.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness or somnolence; caution advised when driving or operating machinery, especially at the start of treatment.
Lifestyle Advice
- Avoid alcohol consumption.
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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