Medicine Information

Bestcol

Name: Bestcol
Brand: Bestcol
Rating: 4.5 (117 reviews)

Tablet10 mgLipid-lowering agentsATC: C10AA07

Generic Name

Rosuvastatin

Manufacturer

Healthcare Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bestcol 10 mg tablet	৳ 25.00	৳ 250.00

Description

Overview of the medicine

Bestcol 10 mg Tablet contains Rosuvastatin, a statin medication used to lower high cholesterol and triglycerides, and to reduce the risk of heart attack, stroke, and other heart-related complications. It works by reducing the amount of cholesterol made by the liver.

Uses & Indications

Primary hypercholesterolemia (Type IIa, including heterozygous familial hypercholesterolemia) or mixed dyslipidemia (Type IIb)

Homozygous familial hypercholesterolemia

Primary prevention of major cardiovascular events in patients at high risk

Dosage

Adults

Initial dose is usually 10 mg once daily. Dosage may be adjusted at 2-4 week intervals up to a maximum of 40 mg once daily, based on lipid levels and patient response.

Elderly

No specific dose adjustment is needed for patients >70 years old; however, a starting dose of 5 mg may be considered.

Renal_impairment

For patients with severe renal impairment (CrCl < 30 mL/min), a starting dose of 5 mg once daily is recommended, and the dose should not exceed 20 mg once daily.

How to Take

Take Bestcol 10 mg Tablet orally, once daily, with or without food. It is generally recommended to take it at approximately the same time each day.

Mechanism of Action

Rosuvastatin competitively inhibits HMG-CoA reductase, an enzyme that catalyzes the early, rate-limiting step in cholesterol biosynthesis. This leads to a reduction in hepatic cholesterol synthesis and an upregulation of LDL receptors on the cell surface, which increases LDL-C uptake and catabolism.

Pharmacokinetics

Onset

Significant lipid-lowering effects are generally seen within 1 week, with maximal effect usually achieved by 2-4 weeks of therapy.

Excretion

Approximately 90% of rosuvastatin is excreted unchanged in the feces, with a smaller portion excreted in the urine.

Half life

The elimination half-life of rosuvastatin is approximately 19 hours.

Absorption

Peak plasma concentrations are achieved approximately 3-5 hours after oral administration. Absolute bioavailability is approximately 20%.

Metabolism

Rosuvastatin undergoes limited metabolism, primarily by CYP2C9 (approximately 10%). The primary metabolite is N-desmethyl rosuvastatin.

Side Effects

Contraindications

Active liver disease, including unexplained persistent elevations of serum transaminases
Pregnancy and lactation
Severe renal impairment (CrCl < 30 mL/min) with high doses (e.g., 40 mg)
Concomitant use of cyclosporine

Drug Interactions

Warfarin

May enhance anticoagulant effect, increasing INR; monitor INR.

Gemfibrozil

Significantly increased rosuvastatin exposure; avoid concomitant use.

Cyclosporine

Increased rosuvastatin exposure; contraindicated.

Erythromycin

Decreased rosuvastatin exposure.

Oral Contraceptives

Increased plasma levels of ethinyl estradiol and norgestrel; dose adjustments may be needed.

Protease Inhibitors (e.g., Atazanavir/Ritonavir, Lopinavir/Ritonavir)

Increased rosuvastatin exposure; dose adjustments or alternative statin recommended.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

There is no specific treatment for rosuvastatin overdose. In the event of an overdose, treatment should be symptomatic and supportive, and liver function and CK levels should be monitored.

Pregnancy & Lactation

Bestcol 10 mg Tablet is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment. If pregnancy occurs, discontinue the drug immediately.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets/strip30 tablets/box (3 strips x 10 tablets)

Shelf Life

Typically 2-3 years from manufacturing date. Refer to the product packaging for exact expiry.

Availability

Pharmacies, Hospitals

Approval Status

Approved by FDA and local regulatory bodies (e.g., DGDA)

Patent Status

Expired in most major markets

Clinical Trials

Key trials for rosuvastatin include the JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) which demonstrated its efficacy in primary prevention, and the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) for plaque regression.

Lab Monitoring

Liver function tests (LFTs) should be performed before initiation of therapy and periodically thereafter.
Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides) should be monitored regularly to assess efficacy.
Creatine kinase (CK) levels should be measured before starting therapy and if muscle pain, tenderness, or weakness develops.

Doctor Notes

Emphasize the importance of lifestyle modifications (diet, exercise) alongside pharmacotherapy.
Monitor LFTs at baseline and as clinically indicated. Evaluate CK levels if muscle symptoms occur.
Caution with concomitant use of drugs interacting with CYP2C9 or OATP1B1.
Advise patients about potential myopathy symptoms and when to seek medical attention.

Patient Guidelines

Take Bestcol 10 mg Tablet exactly as prescribed by your doctor, preferably at the same time each day.
Inform your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or dark urine.
Avoid consuming excessive amounts of grapefruit juice.
Do not stop taking this medication without consulting your doctor, even if you feel well.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Rosuvastatin is not expected to impair the ability to drive or operate machinery. However, dizziness has been reported rarely, so caution is advised until you know how you react to the medication.