Medicine Information

Bukof-Kids

Name: Bukof-Kids
Brand: Bukof-Kids
Rating: 4.5 (117 reviews)

Oral Drop0.5 mg/mLAntihistamineATC: R06AX27

Generic Name

Desloratadine Pediatric Drop

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bukof kids 5 mg pediatric drop	৳ 50.00	N/A

Description

Overview of the medicine

Bukof-Kids 5 mg Pediatric Drop is an antihistamine medication containing Desloratadine, primarily used to relieve symptoms of seasonal allergic rhinitis, perennial allergic rhinitis, and chronic idiopathic urticaria in children. It works by blocking histamine, a substance in the body that causes allergic symptoms.

Uses & Indications

Relief of symptoms associated with seasonal allergic rhinitis (e.g., sneezing, rhinorrhea, nasal itching, ocular itching, tearing, and redness of eyes, palatal itching).

Relief of symptoms associated with perennial allergic rhinitis.

Relief of symptoms associated with chronic idiopathic urticaria (e.g., pruritus and size and number of hives).

Dosage

Adults

Not applicable for this pediatric drop formulation.

Elderly

Not applicable for this pediatric drop formulation.

Children

For children 6-11 months: 1 mL (0.5 mg) once daily. For children 1-5 years: 2 mL (1 mg) once daily. For children 6-11 years: 5 mL (2.5 mg) once daily. Doses should be taken orally with or without food.

Renal_impairment

For children with renal impairment (CrCl < 30 mL/min), initial dose should be 1/2 of the usual recommended dose or administer every other day. Consult a physician.

How to Take

Administer orally using the calibrated dropper provided with the bottle. May be taken with or without food. Ensure proper measurement for pediatric dosing.

Mechanism of Action

Desloratadine is a long-acting tricyclic antihistamine with selective H1-receptor antagonist activity. It inhibits the release of histamine from mast cells and reduces the effects of histamine on H1-receptors, thereby alleviating allergic symptoms such as sneezing, runny nose, itching, and watery eyes.

Pharmacokinetics

Onset

Within 1-3 hours

Excretion

Mainly excreted in urine and feces as conjugated metabolites.

Half life

Approximately 27 hours

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations are reached approximately 3 hours after administration.

Metabolism

Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by cytochrome P450 3A4 and 2D6.

Side Effects

Contraindications

Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
Severe hepatic impairment (use with caution).

Drug Interactions

Fluoxetine

Increases desloratadine plasma concentrations (clinical significance minimal).

Erythromycin

Increases desloratadine plasma concentrations (clinical significance minimal).

Ketoconazole

Increases desloratadine plasma concentrations (clinical significance minimal).

Storage

Store below 30°C in a dry place, away from light. Do not freeze. Keep away from children.

Overdose

Symptoms of overdose may include somnolence, increased heart rate, and headache. In case of overdose, symptomatic and supportive treatment is recommended. Consider standard measures to remove unabsorbed drug.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 mL bottle15 mL bottle30 mL bottle

Shelf Life

24 months from manufacturing date

Availability

Pharmacies, hospitals

Approval Status

Approved (DGDA, FDA)

Patent Status

Generic available (Patent expired)

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of Desloratadine in pediatric and adult populations for allergic rhinitis and chronic urticaria. Studies have focused on symptom relief and long-term tolerability.

Lab Monitoring

No specific routine lab monitoring required for healthy individuals. Liver function tests may be considered in patients with hepatic impairment.

Doctor Notes

Emphasize accurate pediatric dosing using the calibrated dropper to prevent under- or over-dosing.
Advise parents to monitor for any unusual side effects, especially somnolence, though rare.
Review patient's allergy history and current medications for potential interactions, although minimal for Desloratadine.

Patient Guidelines

Follow the prescribed dose and administration instructions carefully.
Use the provided calibrated dropper for accurate dosing.
Do not exceed the recommended dose.
Keep out of reach of children.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Although Desloratadine is a non-sedating antihistamine, individual responses vary. Parents should observe their child for any signs of drowsiness before engaging in activities requiring mental alertness, though this is less common with pediatric drops at recommended doses.