Medicine Information

Butasiv

Name: Butasiv
Brand: Butasiv
Rating: 4.5 (117 reviews)

Syrup75 mg/5 mlNon-Steroidal Anti-Inflammatory Drug (NSAID)ATC: M01AE

Generic Name

Butafenac Sodium

Manufacturer

PharmaCo Bangladesh Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
butasiv 75 mg syrup	৳ 80.00	N/A

Description

Overview of the medicine

Butasiv 75 mg Syrup is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, and inflammation. It is commonly prescribed for conditions like juvenile rheumatoid arthritis, musculoskeletal pain, and post-operative pain in children.

Uses & Indications

Relief of mild to moderate pain

Reduction of fever

Treatment of juvenile rheumatoid arthritis

Management of musculoskeletal pain

Post-operative pain management

Dosage

Adults

Not applicable for this pediatric syrup formulation; adult dosage forms (e.g., higher strength tablets) would be used.

Elderly

Consult physician for appropriate adult dosage form and reduced dose if necessary due to potential renal or hepatic impairment.

Renal_impairment

Use with caution and at reduced doses. Regular monitoring of renal function is recommended. Consult a physician.

How to Take

Administer orally. Shake the bottle well before use. May be taken with food or milk to minimize gastrointestinal upset.

Mechanism of Action

Butafenac Sodium inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing inflammation, pain, and fever.

Pharmacokinetics

Onset

Pain relief usually starts within 30-60 minutes.

Excretion

Primarily excreted in the urine as metabolites, with a small portion excreted in feces.

Half life

Approximately 2-4 hours.

Absorption

Rapidly and completely absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are usually reached within 1-2 hours.

Metabolism

Extensively metabolized in the liver, primarily via oxidation and glucuronidation.

Side Effects

Contraindications

Hypersensitivity to Butafenac Sodium or other NSAIDs.
Active peptic ulcer or gastrointestinal bleeding.
Severe renal or hepatic impairment.
Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Late stages of pregnancy (third trimester).

Drug Interactions

Lithium

Increased plasma lithium levels.

Warfarin

Increased risk of bleeding.

Methotrexate

Increased methotrexate toxicity.

Diuretics and ACE inhibitors

Reduced hypotensive effect and increased risk of renal impairment.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic treatment. Gastric lavage or activated charcoal may be considered within an hour of ingestion.

Pregnancy & Lactation

Use in early pregnancy should be avoided unless clearly necessary. Contraindicated in the third trimester. Excreted in breast milk, caution advised during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml syrup100 ml syrup

Shelf Life

24 months from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Available data supports efficacy and safety in pediatric populations for pain and fever management. Ongoing post-marketing surveillance.

Lab Monitoring

Complete Blood Count (CBC) for long-term use.
Renal function tests (Creatinine, BUN).
Liver function tests (ALT, AST).

Doctor Notes

Advise parents/caregivers on proper dosage based on child's weight/age.
Counsel on potential GI upset and ways to mitigate it.
Emphasize not to combine with other NSAIDs without consultation.

Patient Guidelines

Follow the prescribed dosage and duration strictly.
Do not exceed the recommended dose without consulting a doctor.
Report any unusual side effects to your doctor immediately.
Take with food or milk if stomach upset occurs.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

May cause dizziness or drowsiness in some individuals. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.

Lifestyle Advice

Avoid alcohol consumption during treatment.
Maintain adequate hydration.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Brufen Syrup (Square Pharmaceuticals)Diclopen Syrup (ACME Laboratories)

Global Brand Names

International brand names for this medicine

Incepta Pharmaceuticals

Tablet10 mg

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