Medicine Information

Calpin-plus

Name: Calpin-plus
Brand: Calpin-plus
Rating: 4.5 (117 reviews)

TabletAmlodipine 5 mg + Atenolol 50 mgAntihypertensiveATC: C07FB03

Generic Name

Amlodipine 5 mg + Atenolol 50 mg

Manufacturer

Reputable generic pharmaceutical company

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
calpin plus 5 mg tablet	৳ 6.00	৳ 60.00

Description

Overview of the medicine

Calpin-plus 5 mg tablet is a combination medicine used to treat high blood pressure (hypertension) and angina pectoris. It combines Amlodipine, a calcium channel blocker, and Atenolol, a beta-blocker, to provide a synergistic effect in lowering blood pressure and reducing cardiac workload.

Uses & Indications

Hypertension (high blood pressure)

Chronic Stable Angina

Vasospastic Angina (Prinzmetal's Angina)

Dosage

Adults

The usual starting dose is one Calpin-plus 5 mg tablet once daily. The dose may be adjusted by a physician based on response.

Elderly

Elderly patients may require a lower starting dose and careful monitoring due to potential for increased sensitivity.

Renal_impairment

No dosage adjustment is generally required for amlodipine. Atenolol dose should be adjusted in patients with severe renal impairment. Consult physician for specific recommendations.

How to Take

Take the tablet orally, with or without food. It is recommended to take it at the same time each day for better blood pressure control.

Mechanism of Action

Amlodipine relaxes and widens blood vessels, allowing blood to flow more easily, thereby lowering blood pressure. Atenolol works by blocking certain natural chemicals in your body, like epinephrine, that affect the heart and blood vessels. This effect lowers your heart rate, blood pressure, and strain on your heart.

Pharmacokinetics

Onset

Amlodipine: Gradual onset, full effect within 6-12 hours. Atenolol: Within 1 hour.

Excretion

Amlodipine: Primarily excreted in the urine as inactive metabolites. Atenolol: Approximately 50% of the absorbed dose is excreted unchanged in the urine.

Half life

Amlodipine: 30-50 hours. Atenolol: 6-7 hours.

Absorption

Amlodipine is well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 6-12 hours post-dose. Atenolol is incompletely absorbed from the gastrointestinal tract (50-60%), with peak plasma concentrations occurring 2-4 hours.

Metabolism

Amlodipine is extensively metabolized in the liver to inactive metabolites. Atenolol undergoes minimal hepatic metabolism.

Side Effects

Contraindications

Cardiogenic shock
Sick sinus syndrome (without a pacemaker)
Second- or third-degree AV block (without a pacemaker)
Severe bradycardia (heart rate < 45-50 bpm)
Decompensated heart failure
Severe hypotension
Known hypersensitivity to amlodipine, atenolol, or any component of the formulation

Drug Interactions

Digoxin

Concomitant use with atenolol may increase the risk of bradycardia and AV block.

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)

May reduce the antihypertensive effects of beta-blockers and amlodipine.

Antidiabetic agents (Insulin, oral hypoglycemics)

Atenolol may mask symptoms of hypoglycemia (e.g., tachycardia) and prolong hypoglycemic episodes.

Diltiazem or Verapamil (other calcium channel blockers)

May potentiate the negative inotropic and chronotropic effects, increasing the risk of bradycardia and heart block.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children. Do not freeze.

Overdose

Symptoms of overdose may include severe hypotension, bradycardia, cardiac failure, and bronchospasm. Management involves symptomatic and supportive treatment, including gastric lavage, activated charcoal, IV fluids for hypotension, atropine for bradycardia, and glucagon for cardiac failure.

Pregnancy & Lactation

Pregnancy Category C for Amlodipine and Category D for Atenolol (especially in 2nd and 3rd trimesters due to potential fetal harm). Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as both drugs are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets (1 strip)30 Tablets (3 strips)

Shelf Life

Typically 24 to 36 months from the date of manufacture, when stored under recommended conditions.

Availability

Pharmacies worldwide

Approval Status

Approved by major regulatory bodies globally

Patent Status

Generic available, patents expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical data supports the efficacy and safety of Amlodipine and Atenolol, both individually and in fixed-dose combinations, for the management of hypertension and angina. Numerous studies have demonstrated their sustained blood pressure lowering effects and reduction in cardiovascular events.

Lab Monitoring

Regular monitoring of blood pressure and heart rate.
Renal function (serum creatinine, BUN) and electrolytes (especially potassium) should be monitored periodically.
Liver function tests (LFTs) may be monitored occasionally.

Doctor Notes

Monitor blood pressure and heart rate regularly.
Caution in patients with asthma/COPD due to the beta-blocker component (atenolol).
Advise patients on the importance of adherence and not to discontinue abruptly.
Assess for peripheral edema, especially with amlodipine component.

Patient Guidelines

Take this medicine exactly as prescribed by your doctor.
Do not stop taking this medicine abruptly without consulting your doctor, especially if you have heart disease.
Report any unusual symptoms or side effects to your doctor immediately.
Do not crush, chew, or break the tablet.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

This medicine may cause dizziness, fatigue, or blurred vision, especially at the beginning of treatment or when changing doses. If affected, avoid driving or operating heavy machinery.