Medicine Information

Carboplatin-Sindan

Name: Carboplatin-Sindan
Brand: Carboplatin-Sindan
Rating: 4.5 (117 reviews)

Injection10 mgAntineoplastic Agent (Platinum Compound)ATC: L01XA02

Generic Name

Carboplatin

Manufacturer

Generic Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
carboplatin sindan 10 mg injection	৳ 4,140.00	N/A

Description

Overview of the medicine

Carboplatin is a platinum-based chemotherapy drug used to treat various types of cancer, including ovarian cancer, lung cancer, head and neck cancer, and testicular cancer. It works by interfering with the DNA of cancer cells, preventing their growth and division.

Uses & Indications

Advanced ovarian carcinoma

Small cell lung cancer

Non-small cell lung cancer

Head and neck squamous cell carcinoma

Testicular germ cell tumors

Bladder cancer

Dosage

Adults

Typically 300-400 mg/m² IV every 4 weeks, or AUC-targeted dosing (e.g., AUC 4-6 mg/mL•min) based on Calvert formula, usually in combination with other agents.

Elderly

Dose adjustments may be necessary due to potential age-related decrease in renal function and bone marrow reserve. Renal function should be carefully monitored.

Renal_impairment

Significant dose reduction required. Dosing based on estimated GFR using Calvert formula is crucial. Avoid in severe renal impairment (CrCl < 30 mL/min).

How to Take

Administered as a slow intravenous infusion over 15 minutes to 1 hour, usually diluted in 5% Dextrose or 0.9% Sodium Chloride solution. Must be administered by personnel experienced in anticancer therapy with appropriate facilities for managing complications.

Mechanism of Action

Carboplatin acts as an alkylating-like agent, forming interstrand and intrastrand DNA cross-links. This disrupts DNA replication and transcription, leading to programmed cell death (apoptosis) in cancer cells.

Pharmacokinetics

Onset

Rapid distribution with peak plasma platinum concentrations achieved by the end of infusion.

Excretion

Primarily excreted by the kidneys; approximately 70% of the dose is excreted in the urine within 24 hours.

Half life

Initial alpha half-life of 60 minutes, terminal beta half-life of 2-6 hours for the parent compound; for total platinum, elimination is slower.

Absorption

After intravenous administration, carboplatin is rapidly distributed, achieving 100% bioavailability.

Metabolism

Undergoes non-enzymatic hydration to form active and inactive platinum complexes.

Side Effects

Contraindications

Severe myelosuppression (e.g., platelet counts < 50,000/mm³)
Severe renal impairment (CrCl < 30 mL/min)
History of severe allergic reactions to carboplatin or other platinum-containing compounds
Pregnancy and breastfeeding
Pre-existing severe hearing impairment

Drug Interactions

Phenytoin

May decrease phenytoin levels, requiring monitoring of phenytoin concentration and potential dose adjustment.

Live vaccines

Avoid live vaccines due to immunosuppressive effects of carboplatin.

Loop diuretics

Increased risk of ototoxicity, especially in patients with pre-existing renal impairment.

Aminoglycosides

Increased risk of nephrotoxicity and ototoxicity when co-administered.

Other myelosuppressive agents

Additive myelosuppression, requiring careful monitoring of blood counts and potential dose adjustments.

Storage

Store intact vials at controlled room temperature (20-25°C), protected from light. Do not freeze. Reconstituted and diluted solutions should be used within 24 hours when stored at room temperature or within a longer period (e.g., 8 days) when refrigerated (2-8°C), as per manufacturer guidelines.

Overdose

Overdose with carboplatin can result in severe myelosuppression, leading to fatal infections or hemorrhage. Other toxicities include severe renal and hepatic dysfunction, neurotoxicity, and ototoxicity. There is no specific antidote. Management involves supportive care, including blood transfusions, granulocyte colony-stimulating factors, and close monitoring of vital signs and organ function.

Pregnancy & Lactation

Carboplatin can cause fetal harm when administered to a pregnant woman. It is contraindicated during pregnancy. Women of childbearing potential should be advised to avoid becoming pregnant and use effective contraception during and for at least 6 months after treatment. It is unknown whether carboplatin is excreted in human milk, but due to potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during therapy.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 mg/5 mL vial10 mg/10 mL vial50 mg/5 mL vial150 mg/15 mL vial450 mg/45 mL vial

Shelf Life

Typically 24 to 36 months from the manufacturing date, as indicated on the package. Reconstituted and diluted solutions have specific stability periods.

Availability

Hospitals, Oncology Clinics

Approval Status

Approved

Patent Status

Generic available (off-patent)

WHO Essential Medicine

Yes

Clinical Trials

Carboplatin has been extensively studied in numerous clinical trials, establishing its efficacy and safety in various solid tumors, particularly ovarian, lung, and head and neck cancers. Ongoing research explores its optimal use in combination therapies, new indications, and personalized medicine approaches based on tumor biology and patient genomics.

Lab Monitoring

Complete Blood Count (CBC) with differential (weekly or before each cycle)
Renal function tests (serum creatinine, BUN, GFR calculation) before each cycle
Liver function tests (ALT, AST, ALP, bilirubin) periodically
Electrolyte levels (especially magnesium, potassium, calcium) before each cycle
Audiometric testing (periodically, especially with prior ototoxic agents or high cumulative doses)

Doctor Notes

Administer only under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents and with adequate facilities for patient monitoring and emergency management.
Monitor complete blood counts, renal function, and electrolytes before each cycle and periodically thereafter. Dose adjustments are crucial for myelosuppression and renal impairment.
Pre-medication for nausea and vomiting (e.g., 5-HT3 antagonists, corticosteroids) is highly recommended and often necessary.
Be aware of the potential for hypersensitivity reactions, which can occur at any cycle, and have resuscitation equipment readily available.

Patient Guidelines

Report any signs of infection (fever, chills, sore throat) immediately to your healthcare provider.
Stay well hydrated during and after treatment as advised by your doctor.
Report any unusual bleeding, bruising, or petechiae.
Inform your doctor about any changes in hearing, balance, or numbness/tingling in hands or feet.
Avoid contact with people who are sick or have infections, and wash hands frequently.
Use effective contraception during and for a period after treatment (for both men and women).

Missed Dose Advice

This medicine is administered under strict medical supervision and on a specific schedule. If a dose is missed or delayed, inform your doctor immediately. Do not attempt to adjust the dose or schedule on your own, as it can significantly impact treatment efficacy and safety.

Driving Precautions

Carboplatin may cause fatigue, dizziness, or visual disturbances. Patients should be advised to exercise caution when driving or operating machinery if they experience these effects. Avoid such activities until you know how the medicine affects you.

Lifestyle Advice

Maintain good oral hygiene to prevent mouth sores and infections.
Eat a balanced diet to support recovery, avoiding raw or undercooked foods.
Get adequate rest to manage fatigue.
Discuss fertility preservation options with your doctor before starting treatment if planning for future family.
Avoid alcohol and tobacco products.

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