Medicine Information

Cardinex

Name: Cardinex
Brand: Cardinex
Rating: 4.5 (117 reviews)

Solution for Injection (Prefilled Syringe)8000 anti-Xa IU / 0.8 mL (80 mg)AnticoagulantATC: B01AB05

Generic Name

Enoxaparin Sodium

Manufacturer

Hypothetical Pharma Co.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cardinex 8000 anti xa injection	৳ 630.00	N/A

Description

Overview of the medicine

Cardinex-8000 Anti-Xa Injection contains enoxaparin sodium, a low molecular weight heparin, used to prevent and treat blood clots in various medical conditions.

Uses & Indications

Prophylaxis of deep vein thrombosis (DVT) in surgical patients (e.g., orthopedic, general surgery)

Treatment of DVT and pulmonary embolism (PE)

Prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction (NSTEMI)

Prophylaxis of thrombus formation in extracorporeal circulation during hemodialysis

Dosage

Adults

For treatment of DVT/PE: 1 mg/kg (100 anti-Xa IU/kg) subcutaneously every 12 hours. For an 80 kg individual, this would be 80 mg (8000 anti-Xa IU) every 12 hours. Dosage for other indications may vary.

Elderly

No dose adjustment generally required unless severe renal impairment. Monitor closely for signs of bleeding.

Renal_impairment

Severe renal impairment (CrCl < 30 mL/min): Dose reduction typically required; for treatment, 1 mg/kg (100 anti-Xa IU/kg) once daily.

How to Take

Administer by subcutaneous injection into the anterolateral or posterolateral abdominal wall. Alternate injection sites. Do not inject intramuscularly. Do not mix with other injections.

Mechanism of Action

Potentiates the action of antithrombin III, leading to selective inhibition of Factor Xa and, to a lesser extent, Factor IIa (thrombin). This results in antithrombotic activity.

Pharmacokinetics

Onset

Approximately 1 hour (anti-Xa activity) following SC injection.

Excretion

Mainly renal, with 10-40% of anti-Xa activity excreted unchanged in urine.

Half life

About 4.5 to 7 hours following a single SC dose, longer in renal impairment.

Absorption

Rapid and complete absorption after subcutaneous (SC) injection, with peak anti-Xa activity achieved within 3-5 hours.

Metabolism

Primarily in the liver via desulfation and depolymerization to less active or inactive metabolites.

Side Effects

Contraindications

Active major bleeding
History of heparin-induced thrombocytopenia (HIT) with or without thrombosis
Hypersensitivity to enoxaparin, heparin, or porcine products
Acute bacterial endocarditis
Severe uncontrolled hypertension
Recent hemorrhagic stroke

Drug Interactions

Dextran

Increased risk of bleeding.

Oral Anticoagulants (e.g., Warfarin)

Increased risk of bleeding; requires careful monitoring (e.g., INR) when co-administered.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

Increased risk of bleeding, especially gastrointestinal.

Antiplatelet Agents (e.g., Aspirin, Clopidogrel)

Increased risk of bleeding.

Storage

Store below 30°C. Do not freeze. Protect from light and moisture. Keep in the original packaging. Keep out of reach and sight of children.

Overdose

Overdose may lead to hemorrhagic complications. Manage with protamine sulfate, which partially neutralizes the anti-Xa activity. The dosage of protamine depends on the enoxaparin dose and the time since administration. Consult emergency medical services immediately.

Pregnancy & Lactation

Pregnancy category B. Use with caution during pregnancy if clearly needed, as insufficient data exist regarding human pregnancy. Enoxaparin is excreted into breast milk in very small amounts and is generally considered compatible with breastfeeding, but consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 prefilled syringe of 0.8 mL (80 mg/8000 anti-Xa IU)Box of 2 prefilled syringesBox of 10 prefilled syringes

Shelf Life

Typically 2 to 3 years from the date of manufacture. Always check the expiry date on the product packaging.

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of enoxaparin in various thromboprophylactic and therapeutic indications, demonstrating its superiority or non-inferiority compared to unfractionated heparin in many settings.

Lab Monitoring

Complete Blood Count (CBC) including platelet count (before and during treatment)
Anti-Xa levels (recommended for specific populations like renal impairment, obesity, pregnancy, or if anticoagulant effect is unclear)
Renal function (CrCl) monitoring regularly

Doctor Notes

Careful patient selection and thorough monitoring for bleeding complications are essential.
Adjust dose in severe renal impairment (CrCl < 30 mL/min).
Consider anti-Xa level monitoring in high-risk patients (e.g., extreme weight, renal failure, pregnancy) or when the anticoagulant effect is uncertain.
Educate patients on proper injection technique and recognition of bleeding signs.

Patient Guidelines

Follow injection technique instructions carefully as provided by your healthcare provider.
Report any unusual bleeding or bruising, black or tarry stools, or persistent fever immediately to your doctor.
Do not take other blood thinners, NSAIDs, or aspirin without consulting your doctor.
Inform all healthcare providers, including dentists, about your enoxaparin use before any procedure.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. Contact your doctor for advice.

Driving Precautions

Cardinex is not known to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid driving or operating heavy machinery.

Lifestyle Advice

Avoid activities that may increase the risk of injury or bleeding (e.g., contact sports, vigorous brushing).
Maintain good hydration.
Wear a medical alert bracelet or carry an ID card indicating your anticoagulant therapy.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Inox (Square Pharmaceuticals)Enox (Beximco Pharmaceuticals)Enoxarin (ACI Pharmaceuticals)Enoxaron (General Pharmaceuticals)

Global Brand Names

International brand names for this medicine

Acme Laboratories Ltd.

TabletParacetamol 500 mg + Caffeine 65 mg

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