Medicine Information

Cefotime

Name: Cefotime
Brand: Cefotime
Rating: 4.5 (117 reviews)

Injection (Powder for solution)500 mg3rd Generation CephalosporinsATC: J01DD09

Generic Name

Cefotime 500 mg Injection

Manufacturer

Various Manufacturers

Country

Global

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cefotime 500 mg injection	৳ 87.00	N/A

Description

Overview of the medicine

Cefotime is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is administered via injection.

Uses & Indications

Respiratory tract infections (e.g., pneumonia, bronchitis)

Urinary tract infections

Skin and soft tissue infections

Bone and joint infections

Intra-abdominal infections (e.g., peritonitis)

Meningitis

Sepsis/Septicemia

Gonorrhea (uncomplicated)

Dosage

Adults

Usual dose is 1-2 g IM/IV every 8-12 hours. In severe infections, up to 12 g/day in divided doses.

Elderly

Dosage adjustment may be necessary based on renal function and overall health status.

Renal_impairment

Dosage should be reduced based on creatinine clearance. For CrCl < 20 mL/min, a reduced dose is required (e.g., half the usual dose at the usual interval).

How to Take

Administer by deep intramuscular (IM) injection or slow intravenous (IV) injection/infusion. For IV administration, reconstitute the powder with sterile water for injection, and administer over 3-5 minutes or as an infusion over 20-60 minutes.

Mechanism of Action

Cefotime is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), leading to the disruption of the cell wall and subsequent bacterial cell lysis and death.

Pharmacokinetics

Onset

Rapid onset, typically within minutes after IV administration.

Excretion

Primarily excreted unchanged in the urine via glomerular filtration and tubular secretion.

Half life

Approximately 1-1.5 hours in adults with normal renal function.

Absorption

Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration.

Metabolism

Minor hepatic metabolism to a less active metabolite.

Side Effects

Contraindications

Known hypersensitivity to cefotime or any other cephalosporin antibiotics.
History of severe hypersensitivity reaction to any other beta-lactam antibiotics (e.g., penicillins).

Drug Interactions

Probenecid

Increases and prolongs cefotime serum concentrations by decreasing renal tubular secretion.

Aminoglycosides

Concurrent use may increase the risk of nephrotoxicity.

Oral Anticoagulants (e.g., Warfarin)

May enhance the anticoagulant effect by altering gut flora; monitor INR.

Storage

Store the dry powder below 25°C, protected from light and moisture. Do not freeze. Refer to product insert for specific storage instructions of reconstituted solution.

Overdose

Symptoms of overdose may include convulsions, encephalopathy. Treatment is symptomatic and supportive. Hemodialysis may be useful in removing cefotime from the body.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus. Use during pregnancy only if clearly needed. Cefotime is excreted in small amounts in breast milk; use with caution in breastfeeding mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Single vial of 500 mg powder for injection

Shelf Life

Typically 2-3 years when stored as dry powder. Reconstituted solutions have limited shelf life (e.g., 24 hours at room temperature, 7-10 days under refrigeration).

Availability

Hospitals, Pharmacies

Approval Status

Approved by major regulatory bodies

Patent Status

Generic available

Clinical Trials

Cefotime is a well-established antibiotic. Most clinical trials validating its efficacy and safety were conducted in the 1980s and 1990s, demonstrating its effectiveness against various bacterial infections.

Lab Monitoring

Complete Blood Count (CBC) with differential, especially during prolonged therapy.
Renal function tests (serum creatinine, BUN) in patients with pre-existing renal impairment or during prolonged high-dose therapy.
Liver function tests (AST, ALT) occasionally.

Doctor Notes

Prior to initiating therapy with cefotime, inquire about previous hypersensitivity reactions to cephalosporins, penicillins, or other beta-lactam antibiotics.
Adjust dosage in patients with renal impairment based on creatinine clearance to avoid accumulation and potential toxicity.
Monitor for signs of superinfection or C. difficile-associated diarrhea, especially during prolonged treatment.

Patient Guidelines

Complete the full course of treatment as prescribed by your doctor, even if you feel better.
Report any severe or persistent side effects immediately to your healthcare provider.
Do not share this medicine with others, even if they have similar symptoms.

Missed Dose Advice

If a dose is missed, administer it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Cefotime generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or other side effects that affect your concentration, avoid these activities.