Medicine Information

Cefracef

Name: Cefracef
Brand: Cefracef
Rating: 4.5 (117 reviews)

Capsule250 mgAntibiotic, CephalosporinATC: J01DD08

Generic Name

Cefixime

Manufacturer

Aron Pharma

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cefracef 250 mg capsule	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Cefixime is a broad-spectrum cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by preventing the growth of bacteria.

Uses & Indications

Uncomplicated urinary tract infections

Otitis media

Pharyngitis and tonsillitis

Acute bronchitis and acute exacerbations of chronic bronchitis

Uncomplicated gonorrhea (cervical/urethral)

Dosage

Adults

250 mg orally twice daily or 400 mg once daily, depending on the infection severity and type. Duration usually 7-14 days.

Elderly

Similar to adults, but renal function should be assessed and dosage adjusted if necessary.

Renal_impairment

For creatinine clearance 21-60 mL/min, dose 300 mg daily. For creatinine clearance <20 mL/min, dose 100-200 mg daily or 200 mg every other day.

How to Take

Administer orally with or without food. Complete the full prescribed course of treatment even if symptoms improve to prevent recurrence and resistance.

Mechanism of Action

Cefixime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and bacterial death.

Pharmacokinetics

Onset

Peak plasma concentrations reached within 2-6 hours.

Excretion

Primarily excreted unchanged in the urine (about 50%) and bile (about 10%) within 24 hours.

Half life

Plasma half-life is typically 3-4 hours.

Absorption

Oral bioavailability is 40-50%, absorption is not significantly affected by food.

Metabolism

Not extensively metabolized in the body; approximately 10-20% may undergo minor metabolism.

Side Effects

Contraindications

Hypersensitivity to cefixime or any other cephalosporin antibiotics.
History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.

Drug Interactions

Nifedipine

May increase cefixime Cmax and AUC.

Carbamazepine

Concomitant use may increase carbamazepine plasma concentrations. Monitor carbamazepine levels.

Oral Anticoagulants (e.g., Warfarin)

Cefixime may increase the anticoagulant effect, leading to increased prothrombin time (PT) or INR. Monitor closely and adjust anticoagulant dose if necessary.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive.

Pregnancy & Lactation

Pregnancy Category B. Cefixime is generally considered safe during pregnancy, but use only if clearly needed and with doctor's advice. Small amounts are excreted in breast milk; caution is advised during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per box20 capsules per box

Shelf Life

36 months from manufacturing date.

Availability

Pharmacies and Hospitals

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has been extensively studied in various clinical trials demonstrating its efficacy and safety in treating a wide range of bacterial infections across different patient populations.

Lab Monitoring

Periodic assessment of renal function is recommended during prolonged therapy.
Monitor complete blood count and liver function tests in patients receiving long-term treatment.

Doctor Notes

Confirm bacterial infection before prescribing, avoid empirical use for viral infections.
Advise patients on the importance of completing the full course to prevent resistance.
Be mindful of potential cross-reactivity in patients with known penicillin allergies.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Complete the entire course of treatment, even if you feel better, to prevent the infection from returning or becoming resistant.
Do not share this medication with others, even if they have similar symptoms.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.