Medicine Information

Cefusil-CV

Name: Cefusil-CV
Brand: Cefusil-CV
Rating: 4.5 (117 reviews)

TabletCefuroxime Axetil 250 mg + Clavulanic Acid 62.5 mgAnti-bacterial (2nd generation Cephalosporins)ATC: J01CR02

Generic Name

Cefuroxime Axetil + Clavulanic Acid

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cefusil cv 250 mg tablet	৳ 35.00	৳ 210.00

Description

Overview of the medicine

Cefusil-CV 250 mg Tablet is a combination antibiotic used to treat a wide range of bacterial infections. It contains Cefuroxime Axetil, a second-generation cephalosporin, and Clavulanic Acid, a beta-lactamase inhibitor, which protects Cefuroxime from degradation by bacterial enzymes.

Uses & Indications

Upper respiratory tract infections (e.g., sinusitis, tonsillitis, pharyngitis)

Lower respiratory tract infections (e.g., acute and chronic bronchitis, pneumonia)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Skin and soft tissue infections (e.g., furunculosis, pyoderma, impetigo)

Otitis media

Gonorrhea (uncomplicated)

Dosage

Adults

For most infections, 250 mg (Cefuroxime) twice daily. For more severe infections or certain conditions like bronchitis/pneumonia, 500 mg (Cefuroxime) twice daily. Take with food. Duration is typically 5-10 days depending on the infection.

Elderly

No specific dose adjustment is generally required unless there is significant renal impairment.

Renal_impairment

Dose adjustment required for severe renal impairment (CrCl < 30 mL/min). Consult physician for specific recommendations.

How to Take

Take orally with food. Food increases the absorption of Cefuroxime Axetil. Do not crush or chew the tablet; swallow it whole.

Mechanism of Action

Cefuroxime, a cephalosporin, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. Clavulanic acid, a beta-lactamase inhibitor, inactivates a wide range of beta-lactamase enzymes produced by bacteria, thus extending the spectrum of activity of cefuroxime against many beta-lactamase-producing strains.

Pharmacokinetics

Onset

Antibacterial effect typically observed within 1-2 hours of administration.

Excretion

Cefuroxime is excreted unchanged primarily by glomerular filtration and tubular secretion via the kidneys. Clavulanic acid is primarily excreted renally, with approximately 25-45% excreted unchanged.

Half life

Cefuroxime: Approximately 1.2 to 1.5 hours. Clavulanic acid: Approximately 1 hour.

Absorption

Cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by esterases in the intestinal mucosa and blood to cefuroxime. Absorption is increased when taken with food. Peak plasma concentrations are achieved approximately 2-3 hours after oral administration. Clavulanic acid is also well absorbed orally.

Metabolism

Cefuroxime is not extensively metabolized in the body. Clavulanic acid is extensively metabolized to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to Cefuroxime, Clavulanic Acid, any other cephalosporin antibiotics, or to any of the excipients.
History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams, carbapenems).

Drug Interactions

Probenecid

Concomitant use with probenecid increases the area under the serum concentration-time curve of cefuroxime and reduces its renal clearance. This can lead to increased and prolonged plasma levels of cefuroxime.

Oral Contraceptives

Antibiotics may decrease the effectiveness of oral contraceptives. Patients should be advised to use additional barrier contraception.

Anticoagulants (e.g., Warfarin)

May enhance the anticoagulant effect; INR monitoring is recommended.

Antacids/H2-receptor antagonists

Drugs that reduce gastric acidity may result in a lower bioavailability of Cefuroxime Axetil. May need to be taken at least 2 hours apart.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Overdose of cephalosporins can cause cerebral irritation leading to convulsions. Management includes symptomatic and supportive measures. Hemodialysis and peritoneal dialysis may be effective in removing cefuroxime and clavulanic acid from the body.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefuroxime and clavulanic acid are excreted in human milk in small quantities; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 tablets

Shelf Life

24 months from manufacturing date

Availability

Available in pharmacies and hospitals

Approval Status

Approved (local regulatory bodies)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of Cefuroxime Axetil and Clavulanic Acid in treating a wide range of bacterial infections. Ongoing post-market surveillance monitors long-term safety and effectiveness.

Lab Monitoring

Routine monitoring of liver and renal function may be considered during prolonged therapy. Complete blood count (CBC) may also be monitored if clinically indicated.

Doctor Notes

Assess patient's history for hypersensitivity reactions to beta-lactams.
Administer with caution in patients with renal impairment; dosage adjustment may be necessary.
Advise patients to complete the full course of treatment to prevent the development of antibiotic resistance.
Monitor for signs of superinfection, especially with prolonged use.

Patient Guidelines

Complete the entire course of medication as prescribed, even if symptoms improve.
Take the tablet with food to enhance absorption and reduce stomach upset.
Do not share your medication with others.
Report any persistent or severe diarrhea to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Cefusil-CV may cause dizziness; patients should be advised to be cautious when driving or operating machinery.

Lifestyle Advice

Maintain adequate hydration by drinking plenty of fluids.
Avoid alcohol consumption during the course of treatment, as it may exacerbate side effects.

Alternative Medicines in Bangladesh

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Pneumocef-CV (Square Pharmaceuticals Ltd.)Cefoxim-CV (Incepta Pharmaceuticals Ltd.)Cefnil-CV (ACME Laboratories Ltd.)Axet-CV (Beximco Pharmaceuticals Ltd.)