Medicine Information

Cepdoxim

Name: Cepdoxim
Brand: Cepdoxim
Rating: 4.5 (117 reviews)

Capsule100 mgAntibiotics (3rd Generation Cephalosporins)ATC: J01DD13

Generic Name

Cefpodoxime Proxetil

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cepdoxim 100 mg capsule	৳ 20.00	৳ 80.00

Description

Overview of the medicine

Cefpodoxime is a third-generation cephalosporin antibiotic used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, and skin infections.

Uses & Indications

Acute bacterial exacerbations of chronic bronchitis

Community-acquired pneumonia

Acute maxillary sinusitis

Pharyngitis and/or tonsillitis

Uncomplicated urinary tract infections

Uncomplicated skin and skin structure infections

Dosage

Adults

The usual adult dosage varies depending on the infection. For most infections (e.g., pharyngitis/tonsillitis), 100 mg every 12 hours for 5-10 days. For complicated infections, it may be 200 mg every 12 hours.

Elderly

No specific dose adjustment required for elderly patients with normal renal function. Adjust dose for renal impairment.

Renal_impairment

For creatinine clearance 10-30 mL/min, administer the usual dose every 24 hours. For <10 mL/min, administer the usual dose every 48 hours. Hemodialysis patients should receive the usual dose after each dialysis session.

How to Take

Take orally, preferably with food, to enhance absorption.

Mechanism of Action

Cefpodoxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Peak plasma concentrations typically occur 2-3 hours after administration.

Excretion

The majority of cefpodoxime is excreted unchanged in the urine, primarily via glomerular filtration and tubular secretion.

Half life

The elimination half-life is approximately 2 to 3 hours.

Absorption

Cefpodoxime proxetil is well absorbed from the gastrointestinal tract and rapidly hydrolyzed to the active metabolite cefpodoxime. Absorption is enhanced by food.

Metabolism

Cefpodoxime proxetil is a prodrug that is de-esterified in the gastrointestinal tract to its active form, cefpodoxime. The active drug itself undergoes minimal hepatic metabolism.

Side Effects

Contraindications

Patients with known hypersensitivity to cefpodoxime, other cephalosporins, or any component of the formulation.
Patients with a history of severe hypersensitivity reactions to penicillin (e.g., anaphylaxis).

Drug Interactions

Probenecid

Reduces the renal excretion of cefpodoxime, leading to increased and prolonged plasma concentrations.

Oral anticoagulants

May enhance the anticoagulant effect when co-administered; monitor INR/PT.

Antacids/H2-receptor antagonists/PPIs

Can decrease the absorption of cefpodoxime, leading to lower plasma concentrations. Administer cefpodoxime at least 2 hours before or after these agents.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of severe overdose, supportive and symptomatic treatment is recommended. Hemodialysis may be useful in removing cefpodoxime from the body, especially in patients with impaired renal function.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Cefpodoxime is excreted in human milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per box14 capsules per box

Shelf Life

Typically 24 to 36 months from manufacturing date.

Availability

Available in pharmacies and hospitals

Approval Status

Approved

Patent Status

Patent expired

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of cefpodoxime in treating various bacterial infections. Ongoing post-marketing surveillance continues to monitor for adverse effects.

Lab Monitoring

Monitor renal function periodically in patients with impaired renal function.
Monitor complete blood count and liver function tests in patients receiving prolonged therapy.

Doctor Notes

Consider culture and sensitivity results before initiating therapy, if feasible.
Monitor for signs of C. difficile infection, especially with prolonged use.
Adjust dose in patients with renal impairment.

Patient Guidelines

Take the medicine for the full prescribed duration, even if symptoms improve.
Take with food to improve absorption and reduce stomach upset.
Inform your doctor if you have a history of allergies, especially to penicillins or other cephalosporins.
Do not share this medication with others.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

May cause dizziness or lightheadedness in some individuals. Exercise caution when driving or operating machinery until you know how Cefpodoxime affects you.