Medicine Information

Cifibet

Name: Cifibet
Brand: Cifibet
Rating: 4.5 (117 reviews)

Tablet100 mgAntibacterial (Quinolone)ATC: J01MA02

Generic Name

Ciprofloxacin

Manufacturer

Acme Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cifibet 100 mg tablet	৳ 15.00	৳ 150.00

Description

Overview of the medicine

Cifibet 100 mg tablet contains Ciprofloxacin, a fluoroquinolone antibiotic used to treat a wide range of bacterial infections.

Uses & Indications

Urinary Tract Infections (UTIs)

Respiratory Tract Infections

Skin and Soft Tissue Infections

Bone and Joint Infections

Gastroenteritis

Gonorrhea

Dosage

Adults

For uncomplicated UTIs, 100-250 mg orally twice daily for 3-7 days. For other infections, 250-750 mg orally twice daily depending on the severity and type of infection.

Elderly

Dosage adjustment may be necessary based on renal function. Generally, lower doses are recommended.

Renal_impairment

Dosage reduction is required for patients with creatinine clearance < 50 mL/min. For CrCl 30-50 mL/min, reduce dose by 50%. For CrCl < 30 mL/min, administer standard dose once daily.

How to Take

Take the tablet orally with water, preferably on an empty stomach (1-2 hours before or after meals) for better absorption, but can be taken with food to minimize GI upset. Avoid taking with dairy products or antacids containing magnesium, aluminum, or calcium.

Mechanism of Action

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of DNA synthesis and bacterial cell death.

Pharmacokinetics

Onset

Within 1-2 hours for antibacterial effect.

Excretion

Primarily renal (40-50% as unchanged drug) and to a lesser extent, fecal (20-35%).

Half life

Approximately 3-5 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, with bioavailability of about 70-80%. Peak plasma concentrations are reached 1-2 hours post-dose.

Metabolism

Limited hepatic metabolism (10-20%) via CYP450 enzymes, resulting in four active metabolites.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other fluoroquinolones
Concurrent administration with Tizanidine
History of tendinitis or tendon rupture associated with fluoroquinolone use

Drug Interactions

NSAIDs

Concurrent use may increase the risk of CNS stimulation and convulsive seizures.

Warfarin

May enhance anticoagulant effects of warfarin, increasing bleeding risk. Monitor INR frequently.

Methotrexate

Increases methotrexate toxicity by inhibiting renal tubular secretion.

Theophylline

Ciprofloxacin can increase theophylline plasma levels, leading to toxicity. Monitor theophylline levels.

Antacids/Dairy products

Reduce ciprofloxacin absorption. Separate administration by at least 2 hours before or 6 hours after.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include renal toxicity, crystalluria, reversible renal impairment, and CNS effects (seizures). Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Maintain adequate hydration. Hemodialysis and peritoneal dialysis are generally not effective.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Ciprofloxacin is excreted in breast milk; caution is advised or consider alternative medication due to potential risk of arthropathy and other serious adverse reactions in the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10's blister)30 tablets (3x10's blister)

Shelf Life

24 months from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Ciprofloxacin has been extensively studied in numerous clinical trials globally, demonstrating its efficacy and safety for a wide range of bacterial infections. Ongoing research continues to monitor its resistance patterns and optimize treatment regimens.

Lab Monitoring

Renal function tests (creatinine, BUN)
Liver function tests (ALT, AST)
Complete blood count (CBC)
INR for patients on warfarin

Doctor Notes

Advise patients on the black box warnings, particularly the risk of tendinitis and tendon rupture, peripheral neuropathy, and CNS effects. Promptly discontinue if these symptoms occur.
Monitor renal function, especially in elderly and renally impaired patients, and adjust dosage accordingly.
Educate patients about potential drug and food interactions, emphasizing separation from dairy and antacids.

Patient Guidelines

Complete the full course of antibiotics as prescribed, even if symptoms improve, to prevent resistance.
Avoid dairy products and antacids around the time of taking this medication.
Stay well-hydrated to prevent crystalluria.
Report any tendon pain, numbness, tingling, or muscle weakness immediately to your doctor.
Avoid excessive sun exposure due to increased photosensitivity.

Missed Dose Advice

If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Cifibet may cause dizziness, lightheadedness, or visual disturbances, which could impair your ability to drive or operate machinery. Exercise caution and avoid such activities until you know how the medicine affects you.

Lifestyle Advice

Maintain good personal hygiene to prevent recurrence of infections.
Avoid smoking and excessive alcohol consumption, as they may worsen some side effects.
Ensure a balanced diet to support overall health during recovery.