Medicine Information

Cilvas

Name: Cilvas
Brand: Cilvas
Rating: 4.5 (117 reviews)

Tablet10 mgAntihypertensiveATC: C08CA16

Generic Name

Cilnidipine 10 mg

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cilvas 10 mg tablet	৳ 10.00	৳ 100.00

Description

Overview of the medicine

Cilvas-10 mg tablet contains Cilnidipine, a dual L-type and N-type calcium channel blocker used for the treatment of essential hypertension. It works by relaxing blood vessels, which lowers blood pressure and improves blood flow.

Uses & Indications

Essential hypertension (high blood pressure)

Hypertension with renal dysfunction

Hypertension with sympathetic overactivity

Dosage

Adults

The usual adult dose is 5-10 mg orally once daily. The dose may be adjusted based on blood pressure response, up to a maximum of 20 mg once daily.

Elderly

A starting dose of 5 mg once daily is generally recommended for elderly patients, with careful titration.

Renal_impairment

No dose adjustment is generally required for patients with mild to moderate renal impairment. Caution and close monitoring are advised in severe renal impairment.

How to Take

Take the tablet orally with a glass of water, with or without food. It is recommended to take the medicine at the same time each day to maintain consistent blood levels.

Mechanism of Action

Cilnidipine blocks both L-type voltage-dependent calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve endings. Blocking L-type channels leads to vasodilation, while blocking N-type channels reduces sympathetic neurotransmitter release, contributing to overall blood pressure reduction and potential renoprotective effects.

Pharmacokinetics

Onset

Blood pressure lowering effect typically begins within 1-2 hours.

Excretion

Approximately 60% of the dose is excreted via feces and about 40% via urine, mainly as metabolites.

Half life

The elimination half-life is approximately 5-8 hours.

Absorption

Rapidly absorbed after oral administration. Peak plasma concentration (Tmax) is reached in about 2-3 hours.

Metabolism

Extensively metabolized in the liver, primarily by the cytochrome P450 3A4 (CYP3A4) enzyme system.

Side Effects

Contraindications

Hypersensitivity to cilnidipine or any other dihydropyridine derivatives.
Cardiogenic shock.
Severe aortic stenosis.

Drug Interactions

Other Antihypertensives

Concomitant use with other antihypertensive agents may result in an additive hypotensive effect.

Strong CYP3A4 inducers (e.g., Rifampicin, Carbamazepine, Phenytoin)

May decrease plasma concentrations of cilnidipine, reducing its efficacy.

Strong CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir)

May increase plasma concentrations of cilnidipine, leading to enhanced effects and potential adverse reactions.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include excessive peripheral vasodilation with marked hypotension, dizziness, and reflex tachycardia. Management is supportive and symptomatic; lay the patient supine with legs elevated, administer intravenous fluids and vasopressors if needed to restore blood pressure. Gastric lavage may be considered soon after ingestion.

Pregnancy & Lactation

Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation due to potential excretion in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip3 strips (30 tablets) per box

Shelf Life

36 months from the date of manufacture.

Availability

Pharmacies and hospitals

Approval Status

Approved by regulatory authorities (e.g., DGDA)

Patent Status

Generic available, likely off-patent

Clinical Trials

Cilnidipine has undergone several clinical trials demonstrating its efficacy in lowering blood pressure and improving cardiovascular outcomes. Some studies suggest renoprotective effects and benefits in patients with sympathetic overactivity due to its dual L/N-type calcium channel blocking action.

Lab Monitoring

Regular blood pressure monitoring.
Periodic assessment of renal function (serum creatinine, BUN) and liver function tests (ALT, AST).

Doctor Notes

Cilnidipine's unique dual L/N-type calcium channel blocking mechanism offers advantages, particularly in patients with hypertension complicated by renal dysfunction or high sympathetic tone.
Advise patients about potential peripheral edema and counsel on lifestyle modifications.

Patient Guidelines

Take Cilvas-10 mg tablet exactly as prescribed by your doctor.
Do not stop taking this medicine suddenly without consulting your doctor, even if your blood pressure seems normal.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Report any new or worsening side effects to your healthcare provider promptly.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Cilvas-10 mg tablet may cause dizziness or lightheadedness, especially when starting treatment or increasing the dose. If affected, avoid driving or operating heavy machinery.

Lifestyle Advice

Adopt a healthy lifestyle including a balanced diet low in sodium and saturated fats.
Engage in regular physical activity as advised by your doctor.
Maintain a healthy weight, avoid smoking, and limit alcohol intake.
Manage stress effectively through relaxation techniques or hobbies.