Medicine Information

Cip

Eye Ointment0.3% w/vOphthalmic Antibiotics (Fluoroquinolone)ATC: S01AE03

Generic Name

Ciprofloxacin 0.3% Eye Ointment

Manufacturer

PharmaCorp

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cip 03 eye ointment	৳ 32.00	N/A

Description

Overview of the medicine

Ciprofloxacin 0.3% Eye Ointment is a fluoroquinolone antibiotic used to treat bacterial infections of the eye, including conjunctivitis and corneal ulcers.

Uses & Indications

Bacterial conjunctivitis caused by susceptible organisms

Corneal ulcers caused by susceptible organisms

Other superficial ocular infections

Dosage

Adults

For bacterial conjunctivitis: Apply a small ribbon (approx. 1/2 inch) into the conjunctival sac of the affected eye(s) 3 times a day for 7-10 days. For corneal ulcers: Apply a small ribbon every 1-2 hours initially, then decrease frequency.

Elderly

No specific dosage adjustment required for elderly patients.

Renal_impairment

No dosage adjustment needed as systemic absorption is minimal.

How to Take

For topical ophthalmic use only. Wash hands before and after application. Pull down the lower eyelid to create a small pocket and apply a thin strip of ointment. Avoid touching the eye or eyelid with the tip of the tube.

Mechanism of Action

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.

Pharmacokinetics

Onset

Antibacterial effect typically observed within a few hours of administration.

Excretion

Any systemically absorbed ciprofloxacin is primarily excreted unchanged via the kidneys. Locally, it is cleared from the ocular surface and tissues.

Half life

Systemic half-life (if measurable) is 3-5 hours, but topical ophthalmic half-life in ocular tissues is short.

Absorption

Minimal systemic absorption after topical ocular administration. Local absorption into ocular tissues (cornea, conjunctiva, aqueous humor).

Metabolism

Minimal systemic metabolism for ophthalmic application; primarily excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or any other fluoroquinolone
Hypersensitivity to any component of the formulation

Drug Interactions

Other ophthalmic preparations

If using other eye drops or ointments, wait at least 5-10 minutes between applications to prevent washout.

Storage

Store at room temperature (15-30°C), away from moisture and light. Do not freeze. Keep out of reach of children.

Overdose

Accidental overdose with ophthalmic ciprofloxacin is unlikely. If excessive amount is applied, it can be rinsed from the eye with lukewarm water. Symptomatic treatment if accidental ingestion occurs.

Pregnancy & Lactation

Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted in human milk after systemic administration; however, systemic absorption after ophthalmic use is minimal. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

3.5 g tube5 g tube

Shelf Life

24-36 months (unopened). Discard 28 days after opening.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Patent Expired (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials established the efficacy and safety of ciprofloxacin for ocular infections. Bioequivalence studies confirm the interchangeability of generic formulations.

Lab Monitoring

Not generally required for topical ophthalmic use.

Doctor Notes

Advise patients on proper application technique.
Emphasize completing the full course.
Monitor for signs of superinfection or allergic reactions.

Patient Guidelines

Complete the full course of treatment even if symptoms improve.
Do not wear contact lenses during treatment.
Avoid contaminating the tip of the tube.
Report any worsening symptoms or severe irritation to your doctor.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.