Clavusef
Generic Name
clavusef-250-mg-tablet
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clavusef 250 mg tablet | ৳ 35.00 | ৳ 140.00 |
Description
Overview of the medicine
Clavusef-250-mg-tablet is an antibiotic medication combining Cefuroxime Axetil, a cephalosporin antibiotic, and Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat a wide range of bacterial infections susceptible to this combination.
Uses & Indications
Dosage
Adults
One tablet (250 mg Cefuroxime Axetil / 125 mg Clavulanic Acid) twice daily for 5-10 days, depending on the infection severity and type.
Elderly
No specific dosage adjustment needed unless severe renal impairment. Refer to renal impairment dosage.
Renal_impairment
Dosage adjustment required based on creatinine clearance; e.g., for CrCl 10-29 mL/min, administer every 24 hours; for CrCl <10 mL/min, every 48 hours.
How to Take
Orally, preferably with food for enhanced absorption and to minimize gastrointestinal upset. Should be taken at regular intervals.
Mechanism of Action
Cefuroxime Axetil works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Clavulanic Acid is a beta-lactamase inhibitor that protects cefuroxime from degradation by beta-lactamase enzymes produced by resistant bacteria, thereby extending its spectrum of activity.
Pharmacokinetics
Onset
Rapid, typically within 1-2 hours.
Excretion
Mainly excreted unchanged by the kidneys via glomerular filtration and tubular secretion. Clavulanic acid metabolites are also renally excreted.
Half life
Cefuroxime: approximately 1.2-1.5 hours. Clavulanic acid: approximately 1 hour.
Absorption
Cefuroxime Axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed to cefuroxime. Absorption is enhanced with food. Clavulanic acid is well absorbed orally.
Metabolism
Cefuroxime is not significantly metabolized in the liver. Clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, other cephalosporins, penicillins, or clavulanic acid.
- History of severe hypersensitivity reaction to any beta-lactam antibiotic.
Drug Interactions
Warfarin
May enhance anticoagulant effect (monitor INR).
Probenecid
May increase cefuroxime levels by reducing renal tubular secretion.
Oral Contraceptives
May reduce efficacy of oral contraceptives (advise additional contraception).
Antacids/H2 blockers/PPIs
May reduce bioavailability of cefuroxime axetil.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and convulsions in severe cases. Management is supportive, including gastric lavage or activated charcoal, and hemodialysis may be considered in severe renal impairment.
Pregnancy & Lactation
Pregnancy: Category B. Use only if clearly needed. Cefuroxime crosses the placenta. Lactation: Excreted in small amounts in breast milk. Use with caution. Potential for sensitization, diarrhea, and candidiasis in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
The combination of Cefuroxime Axetil and Clavulanic Acid has been extensively studied for its efficacy and safety in treating various bacterial infections in numerous clinical trials.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment).
- Liver function tests (periodically during prolonged therapy).
Doctor Notes
- Emphasize the importance of completing the full course of therapy, even if symptoms improve.
- Advise patients to take the medication with food to enhance absorption and reduce gastrointestinal upset.
- Caution for patients with a history of penicillin allergy due to potential for cross-reactivity with cephalosporins.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Take with food to improve absorption and reduce stomach upset.
- Report any severe or persistent diarrhea.
- Do not share this medicine with others.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment (can exacerbate GI side effects).
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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