Medicine Information

Clindax

Name: Clindax
Brand: Clindax
Rating: 4.5 (117 reviews)

Lotion1% w/vTopical Anti-acne preparations, Antibiotics (topical)ATC: D10AF01

Generic Name

Clindamycin Phosphate

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clindax 1 lotion	৳ 125.85	N/A

Description

Overview of the medicine

Clindax-1 Lotion contains clindamycin phosphate, a lincosamide antibiotic, formulated for topical application. It is primarily used to treat acne vulgaris by inhibiting bacterial growth and reducing inflammatory lesions.

Uses & Indications

Acne vulgaris

Inflammatory acne lesions

Dosage

Adults

Apply a thin layer to the affected area twice daily, morning and evening.

Elderly

No specific dosage adjustment required for elderly, use as for adults.

Renal_impairment

Not applicable for topical use due to minimal systemic absorption.

How to Take

For external use only. Apply a thin film to the affected skin area after washing and drying. Gently rub in. Wash hands thoroughly after application.

Mechanism of Action

Clindamycin binds to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting bacterial protein synthesis. In the treatment of acne, it targets *Cutibacterium acnes* (formerly *Propionibacterium acnes*), reducing bacterial proliferation and inflammation.

Pharmacokinetics

Onset

Clinical improvement often seen within 4-6 weeks.

Excretion

Systemically, excreted via urine and feces. Topical absorption is minimal.

Half life

Systemic half-life is 2.4-3 hours (if absorbed), but topical effects are localized.

Absorption

Minimal systemic absorption. Some absorption occurs through the skin.

Metabolism

Systemically, metabolized in the liver to inactive metabolites. Topical absorption is minimal.

Side Effects

Contraindications

Hypersensitivity to clindamycin, lincomycin, or any component of the formulation
History of regional enteritis or ulcerative colitis
History of antibiotic-associated colitis

Drug Interactions

Erythromycin topical

May antagonize the action of clindamycin.

Benzoyl Peroxide topical

Concurrent use may increase skin irritation or reduce clindamycin effectiveness.

Neuromuscular blocking agents

Clindamycin has neuromuscular blocking properties and may enhance the action of other neuromuscular blocking agents.

Storage

Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Overdose with topical clindamycin is unlikely due to minimal systemic absorption. If accidental ingestion occurs, seek medical advice. Management is generally supportive.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is not known if clindamycin is excreted in human milk after topical application, but caution is advised in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

15 mL bottle30 mL bottle

Shelf Life

Typically 24-36 months from manufacturing date when stored correctly.

Availability

Available in pharmacies and drug stores

Approval Status

Approved by DGDA

Patent Status

Generic, patent expired

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of topical clindamycin for the treatment of acne vulgaris. Studies often compare it to placebo or other topical agents, sometimes in combination therapies.

Lab Monitoring

No routine lab monitoring is required for topical clindamycin due to minimal systemic absorption.

Doctor Notes

Advise patients on the importance of consistent application for optimal results.
Consider combination therapy with retinoids or benzoyl peroxide for enhanced efficacy, but monitor for increased irritation.
While rare, counsel patients to report severe or persistent diarrhea, as *C. difficile* associated colitis is a potential, albeit very low, risk with topical clindamycin.

Patient Guidelines

For external use only. Avoid contact with eyes, mouth, nose, and any open cuts or irritated skin.
Do not use on sunburned, windburned, dry, chapped, or broken skin.
Use sunscreen and wear protective clothing when outdoors.
Be consistent with application for best results.
Inform your doctor if irritation or allergic reaction occurs.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.