Medicine Information

Clodal

Name: Clodal
Brand: Clodal
Rating: 4.5 (117 reviews)

Cream0.05% w/wTopical CorticosteroidATC: D07AD01

Generic Name

Clobetasol Propionate 0.05%

Manufacturer

Reputable Pharmaceutical Company

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clodal 1 cream	৳ 25.00	N/A

Description

Overview of the medicine

Clodal-1-cream contains clobetasol propionate, a highly potent corticosteroid, used for short-term treatment of inflammatory skin conditions unresponsive to less potent corticosteroids.

Uses & Indications

Short-term treatment of more resistant dermatoses such as psoriasis, recalcitrant eczemas, lichen planus, discoid lupus erythematosus, and other conditions unresponsive to less potent steroids.

Dosage

Adults

Apply a thin film to the affected skin areas once or twice daily for a maximum of 2 weeks. Do not exceed 50g per week.

Elderly

Use with caution; consider reduced frequency or duration.

Renal_impairment

No specific dosage adjustment needed for topical application, but systemic absorption should be monitored if used extensively.

How to Take

For external use only. Apply a thin layer to the affected area. Do not cover with occlusive dressings unless directed by a doctor. Wash hands before and after application.

Mechanism of Action

Clobetasol propionate is a highly potent corticosteroid that works by activating natural substances in the skin to reduce swelling, redness, and itching. It inhibits the release of inflammatory mediators like prostaglandins and leukotrienes.

Pharmacokinetics

Onset

Within hours to days of application.

Excretion

Renal excretion of metabolites.

Half life

Systemic half-life not well established for topical application; for absorbed clobetasol, it is short.

Absorption

Minimal systemic absorption through intact skin; absorption increases with skin damage, occlusion, and application to large surface areas.

Metabolism

Primarily hepatic, similar to other corticosteroids.

Side Effects

Contraindications

Hypersensitivity to clobetasol propionate or other corticosteroids
Rosacea
Acne vulgaris
Perioral dermatitis
Pruritus without inflammation
Perianal and genital pruritus
Fungal or viral infections
Children under 1 year of age.

Drug Interactions

Systemic Corticosteroids

Increased risk of systemic corticosteroid side effects if used concurrently due to potential additive effects. Minimal systemic absorption limits significant topical-systemic drug interactions.

Storage

Store below 30°C. Do not freeze. Keep out of reach of children.

Overdose

Acute overdose is unlikely with topical application. Chronic overdose or misuse can lead to systemic corticosteroid effects, including Cushing's syndrome, hyperglycemia, and HPA axis suppression. Management involves gradual withdrawal under medical supervision.

Pregnancy & Lactation

Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Clobetasol is classified as Pregnancy Category C. Exercise caution when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10g tube20g tube

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Pharmacies nationwide

Approval Status

Approved

Patent Status

Expired

Clinical Trials

Extensively studied and widely used since its introduction. Ongoing post-marketing surveillance and studies on long-term effects and specific populations.

Lab Monitoring

Monitor for signs of HPA axis suppression (e.g., plasma cortisol levels) with extensive or prolonged use, especially in children.

Doctor Notes

Emphasize short-term use for resistant conditions.
Educate patients on proper application technique and potential side effects.
Monitor for signs of HPA axis suppression in high-risk patients (children, large surface area application, occlusive dressings).

Patient Guidelines

Use exactly as directed by your doctor.
Do not use for longer than prescribed (usually 2 weeks).
Avoid contact with eyes, mouth, and other mucous membranes.
Do not cover treated areas with airtight dressings unless advised by a doctor.
Inform your doctor if your condition does not improve or worsens.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.