Medicine Information

Clogfree

Name: Clogfree
Brand: Clogfree
Rating: 4.5 (117 reviews)

Tablet75 mgAntiplateletATC: B01AC04

Generic Name

Clopidogrel

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clogfree 75 mg tablet	৳ 12.00	৳ 120.00

Description

Overview of the medicine

Clogfree 75 mg Tablet contains Clopidogrel, an antiplatelet medication used to prevent blood clots in patients with heart disease or those at risk of stroke or heart attack.

Uses & Indications

Prevention of atherothrombotic events in patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease (PAD).

Prevention of atherothrombotic and thromboembolic events in acute coronary syndrome (ACS) (unstable angina or non-ST-elevation myocardial infarction) including patients undergoing percutaneous coronary intervention (PCI).

Prevention of atherothrombotic events in patients with ST-elevation myocardial infarction (STEMI) in combination with aspirin.

Dosage

Adults

For acute coronary syndrome: A single 300 mg or 600 mg loading dose, followed by 75 mg once daily. For history of MI, stroke, or PAD: 75 mg orally once daily.

Elderly

No dosage adjustment is generally required for elderly patients.

Renal_impairment

No dosage adjustment is necessary for mild to moderate renal impairment. Use with caution in severe renal impairment.

How to Take

Take orally, once daily, with or without food. Swallow the tablet whole with a glass of water.

Mechanism of Action

Clopidogrel is a prodrug that, upon activation by CYP450 enzymes (mainly CYP2C19), irreversibly binds to the P2Y12 adenosine diphosphate (ADP) receptor on platelets. This binding prevents ADP from activating the glycoprotein IIb/IIIa complex, thereby inhibiting platelet aggregation and the formation of blood clots.

Pharmacokinetics

Onset

Antiplatelet effect within 2 hours; maximal effect within 3-7 days of daily dosing.

Excretion

Approximately 50% renal and 46% fecal excretion within 120 hours of administration.

Half life

Parent drug: approximately 8 hours; Active metabolite: approximately 30 minutes.

Absorption

Rapidly absorbed after oral administration; however, the extent of absorption is at least 50%. It is a prodrug.

Metabolism

Primarily hepatic by CYP450 enzymes (e.g., CYP2C19, CYP1A2, CYP2B6, CYP3A4) to an active metabolite and inactive carboxylic acid derivatives.

Side Effects

Contraindications

Hypersensitivity to the active substance or any excipients.
Active pathological bleeding, such as peptic ulcer or intracranial hemorrhage.
Severe hepatic impairment.

Drug Interactions

Warfarin (or other oral anticoagulants)

Increased risk of bleeding due to additive anticoagulant effects. Co-administration should be undertaken with caution.

NSAIDs (Non-Steroidal Anti-inflammatory Drugs)

Increased risk of gastrointestinal bleeding. Concomitant use should be with caution.

Proton Pump Inhibitors (e.g., Omeprazole, Esomeprazole)

May reduce the antiplatelet effect of Clopidogrel by inhibiting CYP2C19. Pantoprazole and Lansoprazole have less impact. Avoid concomitant use of Omeprazole/Esomeprazole if possible.

SSRIs (Selective Serotonin Reuptake Inhibitors) and SNRIs (Serotonin Norepinephrine Reuptake Inhibitors)

Increased risk of bleeding.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Overdose of clopidogrel may lead to prolonged bleeding time and subsequent bleeding complications. Management involves symptomatic treatment and supportive measures. If prolonged bleeding is observed, platelet transfusion may be considered.

Pregnancy & Lactation

Pregnancy: Not recommended during pregnancy unless clearly necessary, as animal studies have shown potential harm. Lactation: It is unknown whether clopidogrel is excreted in human milk. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

36 months from the date of manufacture

Availability

Available in pharmacies nationwide

Approval Status

Approved (internationally and by local drug authorities)

Patent Status

Generic available (original patent expired)

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied in large-scale clinical trials (e.g., CAPRIE, CURE, COMMIT/CCS-2, CLARITY-TIMI 28) demonstrating efficacy in reducing cardiovascular events.

Lab Monitoring

Regular monitoring for signs of bleeding (e.g., CBC with platelet count, PT/INR, aPTT).
Liver function tests may be considered in patients with hepatic impairment or signs of liver dysfunction.

Doctor Notes

Assess bleeding risk factors before initiating therapy and throughout treatment.
Educate patients on bleeding symptoms and the importance of compliance, even if asymptomatic.
Consider genetic testing for CYP2C19 poor metabolizers, especially if there is concern about treatment efficacy.

Patient Guidelines

Take exactly as prescribed by your doctor. Do not stop taking it without consulting your doctor, even if you feel well.
Inform your doctor or dentist that you are taking Clopidogrel before any surgery or dental procedure.
Be aware of increased bleeding risk. Report any unusual bleeding or bruising to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Clopidogrel is unlikely to affect the ability to drive or operate machinery. However, if you experience dizziness, avoid driving or operating machinery.

Lifestyle Advice

Maintain a healthy diet and regular exercise as advised by your doctor to support cardiovascular health.
Avoid activities that may lead to significant injuries or cuts.
Quit smoking and limit alcohol consumption, as these can increase cardiovascular risk and bleeding risk.