Medicine Information

Con

Tablet50 mgAnxiolytic, Hypnotic, SedativeATC: N05BA

Generic Name

con-50-mg-tablet

Manufacturer

XYZ Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
con 50 mg tablet	৳ 8.00	N/A

Description

Overview of the medicine

Con 50 mg Tablet is a medication used for the short-term treatment of anxiety and insomnia. It works by affecting certain brain chemicals to produce a calming effect, helping to reduce feelings of worry and promote sleep.

Uses & Indications

Short-term treatment of generalized anxiety disorder

Insomnia

Panic disorder with or without agoraphobia

Dosage

Adults

For anxiety: 50 mg once daily at bedtime or 25 mg twice daily. For insomnia: 50 mg at bedtime. Max 100 mg/day.

Elderly

Initiate with a lower dose, typically 25 mg at bedtime, adjusted based on response and tolerability, due to increased sensitivity and potential for adverse effects.

Renal_impairment

No significant dosage adjustment required for mild to moderate renal impairment. Use with caution in severe impairment; consider lower doses.

How to Take

Take orally with water, with or without food. Do not crush, chew, or break the tablet. It should be swallowed whole.

Mechanism of Action

Con acts as a modulator of GABA-A receptors, enhancing the inhibitory effects of GABA in the central nervous system. This leads to increased chloride ion influx, hyperpolarization of neurons, and consequently, anxiolytic, sedative, and hypnotic effects.

Pharmacokinetics

Onset

Within 30-60 minutes after oral administration.

Excretion

Excreted mainly through urine (about 80%) as inactive metabolites, with a small portion excreted in feces.

Half life

Approximately 6-8 hours, depending on individual metabolism.

Absorption

Rapidly absorbed after oral administration, peak plasma concentrations typically reached within 1-2 hours.

Metabolism

Primarily metabolized in the liver via CYP enzymes (e.g., CYP3A4, CYP2C19) into inactive metabolites.

Side Effects

Contraindications

Known hypersensitivity to 'Con' or any components of the tablet
Acute narrow-angle glaucoma
Severe respiratory insufficiency (e.g., sleep apnea, severe COPD)
Severe hepatic impairment
Myasthenia gravis

Drug Interactions

Alcohol

Increased sedative effect and risk of CNS depression, respiratory depression, and hypotension.

Opioids

Significantly increased risk of respiratory depression, profound sedation, coma, and death. Avoid concomitant use if possible.

CYP3A4 inducers (e.g., rifampin, carbamazepine)

May decrease plasma concentrations of 'Con', potentially reducing its efficacy.

CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)

May increase plasma concentrations of 'Con', leading to enhanced effects and adverse reactions.

Other CNS depressants (e.g., other anxiolytics, antihistamines, tricyclic antidepressants)

Additive sedative effects and increased risk of CNS depression.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach and sight of children.

Overdose

Symptoms of overdose typically include severe drowsiness, confusion, lethargy, ataxia, blurred vision, hypotension, and respiratory depression. In severe cases, coma and death can occur. Management involves supportive care, maintaining a patent airway, gastric lavage if ingestion is recent, administration of activated charcoal, and monitoring vital signs. Flumazenil may be considered in appropriate cases but with caution due to seizure risk.

Pregnancy & Lactation

Pregnancy Category D. 'Con' should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is known to cross the placental barrier. 'Con' is excreted in breast milk and may cause sedation and feeding difficulties in breastfed infants; therefore, avoid breastfeeding or discontinue the drug while nursing.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per box30 tablets (3x10) per box

Shelf Life

24 months from the manufacturing date

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Patent Expired

Clinical Trials

Various clinical trials have established the efficacy of 'Con' in reducing anxiety symptoms and improving sleep onset and duration in patients with insomnia. Safety profiles were monitored, showing common mild side effects.

Lab Monitoring

No specific routine laboratory monitoring is required for short-term use.
For prolonged therapy or in patients with hepatic impairment, periodic monitoring of liver function tests (LFTs) may be advised.

Doctor Notes

Advise patients about the short-term nature of treatment and the potential for dependence.
Emphasize the importance of gradual dose tapering to avoid withdrawal symptoms upon discontinuation.
Assess for co-morbid mental health conditions and substance abuse history prior to prescribing.
Caution against concomitant use with alcohol and other CNS depressants.

Patient Guidelines

Take 'Con' exactly as prescribed by your doctor and do not exceed the recommended dose.
Do not stop taking this medicine abruptly without consulting your doctor, as withdrawal symptoms may occur.
Avoid alcohol and other central nervous system depressants while on this medication due to increased sedative effects.
Report any unusual or severe side effects to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

May cause drowsiness, dizziness, and impaired concentration. Patients should be warned not to drive or operate hazardous machinery until they are reasonably certain that 'Con' does not adversely affect their ability to perform such activities.

Lifestyle Advice

Practice good sleep hygiene (e.g., regular sleep schedule, dark quiet bedroom).
Manage stress through relaxation techniques, meditation, or light exercise.
Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness and dizziness.