Medicine Information

Coport-L

Name: Coport-L
Brand: Coport-L
Rating: 4.5 (117 reviews)

Tablet25 mgAntihypertensive (Angiotensin II Receptor Blocker)ATC: C09CA01

Generic Name

Losartan Potassium

Manufacturer

Drug International Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
coport l 25 mg tablet	৳ 50.00	৳ 500.00

Description

Overview of the medicine

Coport-L 25 mg Tablet contains Losartan Potassium, an angiotensin II receptor blocker (ARB) used to treat high blood pressure, protect kidneys in diabetic patients, and reduce the risk of stroke.

Uses & Indications

Treatment of hypertension (high blood pressure).

Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy.

Treatment of kidney disease in patients with type 2 diabetes and proteinuria.

Dosage

Adults

The usual starting dose is 50 mg once daily. However, for some patients (e.g., those with possible intravascular volume depletion), a starting dose of 25 mg once daily may be considered. The dose can be adjusted from 25 mg to 100 mg once daily.

Elderly

No initial dosage adjustment is typically needed for elderly patients. However, a starting dose of 25 mg once daily may be considered for very frail elderly patients.

Renal_impairment

No initial dosage adjustment is necessary for patients with mild to moderate renal impairment. For patients with severe renal impairment (creatinine clearance < 30 mL/min) or on dialysis, a starting dose of 25 mg once daily may be considered.

How to Take

Coport-L 25 mg Tablet should be taken orally, with or without food, usually once daily. It is recommended to take the tablet at about the same time each day.

Mechanism of Action

Losartan selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues, including vascular smooth muscle and the adrenal gland. This prevents the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.

Pharmacokinetics

Onset

Antihypertensive effect usually starts within 6 hours, with maximum effect generally observed after 3-6 weeks of consistent therapy.

Excretion

Approximately 35% of the dose is excreted in the urine and approximately 58% in the feces (bile).

Half life

Losartan has a terminal half-life of approximately 2 hours, and its active metabolite (E-3174) has a half-life of 6-9 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract. Bioavailability is approximately 33%. Peak plasma concentrations of Losartan are reached in about 1 hour and for its active metabolite in 3-4 hours.

Metabolism

Undergoes extensive first-pass metabolism by CYP2C9 and CYP3A4 enzymes to form an active carboxylic acid metabolite (E-3174) and several minor inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to Losartan or any component of the tablet.
Pregnancy (especially during the second and third trimesters).
Concomitant use with Aliskiren in patients with diabetes mellitus.

Drug Interactions

Lithium

Increased serum lithium concentrations and lithium toxicity have been reported. Monitor lithium levels.

ACE Inhibitors

Dual blockade of the renin-angiotensin system by combining Losartan with an ACE inhibitor is not recommended due to increased risk of hypotension, hyperkalemia, and renal impairment.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs) including COX-2 inhibitors

May reduce the antihypertensive effect of Losartan and increase the risk of renal impairment, especially in elderly, volume-depleted, or renally impaired patients.

Potassium-sparing diuretics (e.g., Spironolactone, Triamterene, Amiloride) and Potassium supplements

May lead to increased serum potassium levels (hyperkalemia).

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose typically include hypotension (low blood pressure) and tachycardia (rapid heartbeat); bradycardia (slow heartbeat) may occur. Management involves symptomatic and supportive treatment, including intravenous fluid administration.

Pregnancy & Lactation

Losartan is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal injury and death. It should be discontinued as soon as pregnancy is detected. It is not recommended during breastfeeding, as it is unknown if Losartan is excreted in human milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets (3 x 10's blister pack)50 tablets (5 x 10's blister pack)

Shelf Life

Typically 2-3 years from the date of manufacture, specific details are on the product packaging.

Availability

Available in pharmacies, hospitals, and clinics

Approval Status

Approved by DGDA and internationally

Patent Status

Patent expired, generic versions available

WHO Essential Medicine

Yes

Clinical Trials

Losartan has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in treating hypertension, reducing cardiovascular events, and protecting kidneys in diabetic patients. Key trials include the LIFE study (Losartan Intervention For Endpoint reduction in hypertension study) and the RENAAL study (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan).

Lab Monitoring

Regular monitoring of blood pressure.
Serum potassium levels should be checked periodically, especially in patients with renal impairment or those taking potassium-sparing diuretics.
Renal function (serum creatinine and BUN) should be monitored, particularly in patients with pre-existing renal impairment.
Liver function tests may be considered in patients with pre-existing liver conditions.

Doctor Notes

Monitor blood pressure, renal function (creatinine, BUN), and serum potassium levels regularly, especially when initiating therapy or titrating the dose.
Caution in patients with bilateral renal artery stenosis, severe congestive heart failure, or volume depletion.
Advise female patients of childbearing age about the risk of fetal toxicity if they become pregnant.
Consider lower starting doses in patients with hepatic impairment, as Losartan is primarily metabolized in the liver.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor, even if you feel well.
Do not stop taking Coport-L without consulting your doctor.
Inform your doctor about all other medications, supplements, and herbal products you are taking.
Report any unusual side effects or symptoms to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Coport-L 25 mg Tablet may cause dizziness or lightheadedness, especially when you start treatment or increase your dose. Avoid driving or operating machinery until you know how this medicine affects you.