Medicine Information

Cosmozole

Name: Cosmozole
Brand: Cosmozole
Rating: 4.5 (117 reviews)

Capsule40 mgAnti-ulcerantsATC: A02BC01

Generic Name

Omeprazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cosmozole 40 mg capsule	৳ 8.50	৳ 85.00

Description

Overview of the medicine

Cosmozole 40 mg Capsule contains Omeprazole, a proton pump inhibitor (PPI) used to reduce the amount of acid produced in the stomach. It helps to treat acid-related diseases of the stomach and intestine.

Uses & Indications

Gastroesophageal Reflux Disease (GERD)

Duodenal ulcer

Gastric ulcer

Zollinger-Ellison syndrome

Eradication of Helicobacter pylori (in combination with antibiotics)

Dosage

Adults

Usually 20-40 mg once daily, depending on the indication. For severe GERD or Zollinger-Ellison syndrome, doses up to 120 mg/day may be used.

Elderly

No specific dosage adjustment is generally required, but caution is advised due to potential age-related decrease in renal and hepatic function.

Renal_impairment

No dosage adjustment is necessary for patients with impaired renal function.

How to Take

Take orally, preferably in the morning before breakfast. Capsules should be swallowed whole with water; do not crush, chew, or open the capsule.

Mechanism of Action

Omeprazole works by irreversibly blocking the proton pump (H+/K+-ATPase) in the gastric parietal cells, thereby preventing the secretion of gastric acid into the stomach lumen.

Pharmacokinetics

Onset

Within 1 hour (initial effect), full effect after several days of treatment.

Excretion

Approximately 77% excreted in the urine as metabolites, and the remainder in feces.

Half life

Plasma half-life is approximately 0.5 to 1 hour, but its duration of action on acid secretion is much longer (up to 72 hours).

Absorption

Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 0.5 to 3.5 hours. Bioavailability increases with repeated dosing.

Metabolism

Extensively metabolized in the liver, primarily by the cytochrome P450 enzyme system, mainly CYP2C19 and CYP3A4.

Side Effects

Contraindications

Known hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
Co-administration with nelfinavir.

Drug Interactions

Warfarin

Increased International Normalized Ratio (INR) and prothrombin time; monitor closely.

Clopidogrel

Reduced antiplatelet effect of clopidogrel. Avoid concomitant use if possible.

Methotrexate

Increased and prolonged methotrexate levels; consider temporary PPI discontinuation.

Atazanavir/Nelfinavir

Reduced plasma concentrations of these antiretroviral drugs, leading to loss of therapeutic effect.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, confusion, blurred vision, tachycardia, nausea, vomiting, sweating, headache, dry mouth, and other gastrointestinal disturbances. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Omeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules30 capsules50 capsules

Shelf Life

2-3 years, as indicated on the packaging by the manufacturer.

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory authorities (e.g., DGDA, FDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Omeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in various acid-related disorders. It is a well-established and widely used medication.

Lab Monitoring

No routine lab monitoring is required. However, long-term use may warrant monitoring of magnesium levels and Vitamin B12 levels.

Doctor Notes

Counsel patients on the importance of taking PPIs for the shortest duration and at the lowest effective dose.
Consider magnesium and vitamin B12 supplementation for patients on long-term PPI therapy, especially those at risk.

Patient Guidelines

Take the capsule whole with water, do not chew or crush.
Preferably take it in the morning before breakfast.
Do not stop taking the medicine suddenly without consulting your doctor.
Report any severe or persistent side effects to your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Omeprazole usually does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.